Double-Stranded RNA Immunomodulators in Prostate Cancer

Andres M. Salazar, Esteban Celis

Research output: Contribution to journalReview articlepeer-review

Abstract

Relatively simple, synthetic, double-stranded RNAs can be powerful viral pathogen-associated molecular pattern (PAMP) mimics, inducing a panoply of antiviral and antitumor responses that act at multiple stages of host defense. Their mechanisms of action and uses are beginning to be understood, alone, in combination with other therapeutics, or as novel PAMP-adjuvants providing the critical danger signal that has been missing from most cancer and other modern vaccines. Dose, timing, route of administration combinations, and other clinical variables can have a critical impact on immunogenicity. This article reviews advances in the use of polyinosinic-polycytidylic acid and derivatives, in particular poly-ICLC.

Original languageEnglish (US)
Pages (from-to)e1-e8
JournalUrologic Clinics of North America
Volume47
Issue number4
DOIs
StatePublished - Nov 2020

Keywords

  • Immunotherapy
  • Poly-ICLC
  • Prostate cancer
  • dsRNA

ASJC Scopus subject areas

  • Urology

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