Drugs of abuse and placental transport

Vadivel Ganapathy, Puttur D. Prasad, Malliga E. Ganapathy, Frederick H. Leibach

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

The placenta provides the only link between the mother and the developing fetus. The function of the placenta as a transport organ is obligatory for fetal development because this process, mediated by a variety of transport systems, is responsible for the delivery of nutrients from the mother to the fetus. Some of the transport systems in the placenta also play a role in the clearance of vasoactive compounds, thus maintaining optimal blood flow to this organ. There is strong supporting evidence to indicate that several of these placental transport systems are either direct or indirect targets for the abusable drugs cocaine, amphetamines, nicotine, and cannabinoids. These drugs of abuse compromise the placental transport function and consequently produce detrimental effects on the developing fetus. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)99-110
Number of pages12
JournalAdvanced Drug Delivery Reviews
Volume38
Issue number1
DOIs
StatePublished - Jun 14 1999

Keywords

  • Amino acid transport
  • Amphetamines
  • Cannabinoids
  • Cocaine
  • Extraneuronal monoamine transporter
  • Norepinephrine transporter
  • Serotonin transporter
  • Sigma receptor

ASJC Scopus subject areas

  • Pharmaceutical Science

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