Dual-energy X-ray absorptiometry analysis of implants in rat tibiae

Chirdeep M. Chandrakeerthi, Tim R. Nagy, Jack Lemons, Michael Scott McCracken

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Dual energy x-ray absorptiometry (DXA) was evaluated for its ability to measure changes in bone mineral density in isolated rat tibiae. This technique is available for in vivo use to potentially augment or replace some aspects of conventional histomorphometric techniques used for the evaluation of metallic implant-to-bone interfaces. Known quantities of hydroxyapatite powder, representing various bone densities, were measured using DXA in a series of 3 experiments: (1) the hydroxyapatite powder was placed within a plastic tube, (2) the hydroxyapatite was placed within an excised rat tibia, and (3) hydroxyapatite powder was placed within a rat tibia with soft tissue overlying it. Statistical analysis (analysis of variance) showed significant differences in bone mineral density among groups that varied by only 5% hydroxyapatite density within the plastic tubes. The system detected hydroxyapatite changes of 20% within the tibiae with and without overlying soft tissue (P < 0.05). These data were consistent and linear (R2 > 0.90). Although DXA analysis has been widely used in clinical and research applications for detection of osteoporosis, its use for documenting bone growth around implants has not been widely reported. The use of such a technique could have substantial benefits for both the clinical and research arenas. These data show that DXA analysis to identify bone density changes adjacent to implants has significant applications in small animal research models.

Original languageEnglish (US)
Pages (from-to)294-300
Number of pages7
JournalImplant Dentistry
Volume14
Issue number3
DOIs
StatePublished - Sep 1 2005

Fingerprint

Photon Absorptiometry
Durapatite
Tibia
Bone Density
X-Rays
Powders
Plastics
Bone Development
Research
Osteoporosis
Analysis of Variance
Animal Models

Keywords

  • Animal
  • Bone mineral density
  • Hydroxyapatite
  • Imaging

ASJC Scopus subject areas

  • Oral Surgery

Cite this

Chandrakeerthi, C. M., Nagy, T. R., Lemons, J., & McCracken, M. S. (2005). Dual-energy X-ray absorptiometry analysis of implants in rat tibiae. Implant Dentistry, 14(3), 294-300. https://doi.org/10.1097/01.id.0000173642.43360.70

Dual-energy X-ray absorptiometry analysis of implants in rat tibiae. / Chandrakeerthi, Chirdeep M.; Nagy, Tim R.; Lemons, Jack; McCracken, Michael Scott.

In: Implant Dentistry, Vol. 14, No. 3, 01.09.2005, p. 294-300.

Research output: Contribution to journalArticle

Chandrakeerthi, CM, Nagy, TR, Lemons, J & McCracken, MS 2005, 'Dual-energy X-ray absorptiometry analysis of implants in rat tibiae', Implant Dentistry, vol. 14, no. 3, pp. 294-300. https://doi.org/10.1097/01.id.0000173642.43360.70
Chandrakeerthi, Chirdeep M. ; Nagy, Tim R. ; Lemons, Jack ; McCracken, Michael Scott. / Dual-energy X-ray absorptiometry analysis of implants in rat tibiae. In: Implant Dentistry. 2005 ; Vol. 14, No. 3. pp. 294-300.
@article{608b55e51b6e41b39aa30b86a606e11f,
title = "Dual-energy X-ray absorptiometry analysis of implants in rat tibiae",
abstract = "Dual energy x-ray absorptiometry (DXA) was evaluated for its ability to measure changes in bone mineral density in isolated rat tibiae. This technique is available for in vivo use to potentially augment or replace some aspects of conventional histomorphometric techniques used for the evaluation of metallic implant-to-bone interfaces. Known quantities of hydroxyapatite powder, representing various bone densities, were measured using DXA in a series of 3 experiments: (1) the hydroxyapatite powder was placed within a plastic tube, (2) the hydroxyapatite was placed within an excised rat tibia, and (3) hydroxyapatite powder was placed within a rat tibia with soft tissue overlying it. Statistical analysis (analysis of variance) showed significant differences in bone mineral density among groups that varied by only 5{\%} hydroxyapatite density within the plastic tubes. The system detected hydroxyapatite changes of 20{\%} within the tibiae with and without overlying soft tissue (P < 0.05). These data were consistent and linear (R2 > 0.90). Although DXA analysis has been widely used in clinical and research applications for detection of osteoporosis, its use for documenting bone growth around implants has not been widely reported. The use of such a technique could have substantial benefits for both the clinical and research arenas. These data show that DXA analysis to identify bone density changes adjacent to implants has significant applications in small animal research models.",
keywords = "Animal, Bone mineral density, Hydroxyapatite, Imaging",
author = "Chandrakeerthi, {Chirdeep M.} and Nagy, {Tim R.} and Jack Lemons and McCracken, {Michael Scott}",
year = "2005",
month = "9",
day = "1",
doi = "10.1097/01.id.0000173642.43360.70",
language = "English (US)",
volume = "14",
pages = "294--300",
journal = "Implant Dentistry",
issn = "1056-6163",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Dual-energy X-ray absorptiometry analysis of implants in rat tibiae

AU - Chandrakeerthi, Chirdeep M.

AU - Nagy, Tim R.

AU - Lemons, Jack

AU - McCracken, Michael Scott

PY - 2005/9/1

Y1 - 2005/9/1

N2 - Dual energy x-ray absorptiometry (DXA) was evaluated for its ability to measure changes in bone mineral density in isolated rat tibiae. This technique is available for in vivo use to potentially augment or replace some aspects of conventional histomorphometric techniques used for the evaluation of metallic implant-to-bone interfaces. Known quantities of hydroxyapatite powder, representing various bone densities, were measured using DXA in a series of 3 experiments: (1) the hydroxyapatite powder was placed within a plastic tube, (2) the hydroxyapatite was placed within an excised rat tibia, and (3) hydroxyapatite powder was placed within a rat tibia with soft tissue overlying it. Statistical analysis (analysis of variance) showed significant differences in bone mineral density among groups that varied by only 5% hydroxyapatite density within the plastic tubes. The system detected hydroxyapatite changes of 20% within the tibiae with and without overlying soft tissue (P < 0.05). These data were consistent and linear (R2 > 0.90). Although DXA analysis has been widely used in clinical and research applications for detection of osteoporosis, its use for documenting bone growth around implants has not been widely reported. The use of such a technique could have substantial benefits for both the clinical and research arenas. These data show that DXA analysis to identify bone density changes adjacent to implants has significant applications in small animal research models.

AB - Dual energy x-ray absorptiometry (DXA) was evaluated for its ability to measure changes in bone mineral density in isolated rat tibiae. This technique is available for in vivo use to potentially augment or replace some aspects of conventional histomorphometric techniques used for the evaluation of metallic implant-to-bone interfaces. Known quantities of hydroxyapatite powder, representing various bone densities, were measured using DXA in a series of 3 experiments: (1) the hydroxyapatite powder was placed within a plastic tube, (2) the hydroxyapatite was placed within an excised rat tibia, and (3) hydroxyapatite powder was placed within a rat tibia with soft tissue overlying it. Statistical analysis (analysis of variance) showed significant differences in bone mineral density among groups that varied by only 5% hydroxyapatite density within the plastic tubes. The system detected hydroxyapatite changes of 20% within the tibiae with and without overlying soft tissue (P < 0.05). These data were consistent and linear (R2 > 0.90). Although DXA analysis has been widely used in clinical and research applications for detection of osteoporosis, its use for documenting bone growth around implants has not been widely reported. The use of such a technique could have substantial benefits for both the clinical and research arenas. These data show that DXA analysis to identify bone density changes adjacent to implants has significant applications in small animal research models.

KW - Animal

KW - Bone mineral density

KW - Hydroxyapatite

KW - Imaging

UR - http://www.scopus.com/inward/record.url?scp=26844446796&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26844446796&partnerID=8YFLogxK

U2 - 10.1097/01.id.0000173642.43360.70

DO - 10.1097/01.id.0000173642.43360.70

M3 - Article

C2 - 16160577

AN - SCOPUS:26844446796

VL - 14

SP - 294

EP - 300

JO - Implant Dentistry

JF - Implant Dentistry

SN - 1056-6163

IS - 3

ER -