Dual signaling regulated by Calcyon, a D1 dopamine receptor interacting protein

Nelson Lezcano, Ladislav Mrzljak, Steven Eubanks, Robert Levenson, Patricia Goldman-Rakic, Clare Bergson

Research output: Contribution to journalArticlepeer-review

151 Scopus citations

Abstract

The synergistic response of cells to the stimulation of multiple receptors has been ascribed to receptor cross talk; however, the specific molecules that mediate the resultant signal amplification have not been defined. Here a 24-kilodalton single transmembrane protein, designated calcyon, we functionally characterize that interacts with the D1 dopamine receptor. Calcyon localizes to dendritic spines of D1 receptor-expressing pyramidal cells in prefrontal cortex. These studies delineate a mechanism of G(q)- and G(s)-coupled heterotrimeric GTP-binding protein-coupled receptor cross talk by which D1 receptors can shift effector coupling to stimulate robust intracellular calcium (Ca2+(i)) release as a result of interaction with calcyon. The role of calcyon in potentiating Ca2+-dependent signaling should provide insight into the D1 receptor-modulated cognitive functions of prefrontal cortex.

Original languageEnglish (US)
Pages (from-to)1660-1664
Number of pages5
JournalScience
Volume287
Issue number5458
DOIs
StatePublished - Mar 3 2000

ASJC Scopus subject areas

  • General

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