Duct-penetrating sign at MRCP: Usefulness for differentiating inflammatory pancreatic mass from pancreatic carcinomas

T. Ichikawa, H. Sou, T. Araki, Ali Syed Arbab, T. Yoshikawa, K. Ishigame, H. Haradome, J. Hachiya

Research output: Contribution to journalArticle

169 Scopus citations

Abstract

PURPOSE: To define the duct-penetrating sign at magnetic resonance (MR) cholangiopancreatography (MRCP) and to assess the usefulness of this sign for distinguishing an inflammatory pancreatic mass (IPM) from a conventional pancreatic carcinoma (CPC) compared with arterial phase computed tomography (hereafter, CT) and arterial phase MR imaging (hereafter, MR imaging). MATERIALS AND METHODS: MRCP, CT, and MR images were compared by means of receiver operating characteristic (ROC) analysis for 11 IPMs and 43 CPCs. With the MRCP images, a morphologic classification of the main pancreatic duct (MPD) was attempted for all lesions. On the basis of this classification and the enhancement patterns of a lesion, all readers graded the presence of IPM or CPC on a five-point scale for all images. RESULTS: On the MRCP images, the morphologic characteristics of the MPD were nonobstruction for IPM (28 of 33, 85%) and obstruction or irregular stenosis for CPC (124 of 129, 96%). At ROC analysis among all the techniques, MRCP images had the highest value (0.98) for significant areas under the ROC curve (CT, 0.84; MR, 0.76) (P < .001). For the duct-penetrating sign in the broad sense (nonobstructed MPD) and the sign in the narrow sense (only normal MPD), the sensitivity, specificity, and accuracy for diagnosis of IPM were 85%, 96%, and 94%, respectively, and 36%, 100%, and 87%, respectively. CONCLUSION: The duct-penetrating sign on MRCP images was more helpful to distinguish IPM from CPC than were the enhancement patterns on CT and MR images.

Original languageEnglish (US)
Pages (from-to)107-116
Number of pages10
JournalRadiology
Volume221
Issue number1
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Keywords

  • MR, 770.121411, 770.121412, 77.121415, 770.12143
  • Pancreas, CT, 770.12113, 770.12115 Pancreas
  • Pancreas, neoplasms, 774.321
  • Pancreatitis, 770.291

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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