Dynamic SPET parameters of 123I-MIBG cardiac imaging

Ali Syed Arbab, K. Koizumi, K. Toyama, T. Arai, T. Araki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Early dynamic and late 123I-MIBG SPET studies were performed to investigate several parameters used to distinguish the characteristics of various cardiac disorders. Forty-six individuals (34 non-diabetic, 12 diabetic) with or without heart disease were included in the study. Early dynamic and late static SPET images were acquired using a triple-headed gamma camera. After selecting mid-sections from vertical (VLA) and horizontal (HLA) long-axis images, regions of interest were created over the apex, whole heart and anterior, inferior, septal and lateral walls of the heart. Various uptake ratios at 3,11 and 19 min and 4 h after injection (HU3, HU11, HU19, DUP) and clearances (Kse: between HU3 and HU11; Ke: between HU11 and HU19; Kd: between HU19 and DUP) were calculated. There were significant differences among various cardiac pathologies on the delayed images. Cardiomyopathy patients showed the lowest uptake on the delayed images. When all segments in normal patients and all involved segments in myocardial infarcted patients were compared, there was significantly lower uptake of MIBG in infarcted segments at all time points. Kd showed the lowest value compared with and Ke. In cardiomyopathy patients, Kse, and Kd were significantly different from each other. Both Kse and Ke were significantly higher in cardiomyopathy patients than in normal patients. In conclusion, the results of this study are in line with published data and precise measurement of uptaKe and clearance was possible when excluding background and blood pool activity.

Original languageEnglish (US)
Pages (from-to)617-622
Number of pages6
JournalNuclear Medicine Communications
Volume20
Issue number7
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

Fingerprint

3-Iodobenzylguanidine
Cardiomyopathies
Gamma Cameras
Heart Diseases
Pathology
Injections

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Dynamic SPET parameters of 123I-MIBG cardiac imaging. / Arbab, Ali Syed; Koizumi, K.; Toyama, K.; Arai, T.; Araki, T.

In: Nuclear Medicine Communications, Vol. 20, No. 7, 01.01.1999, p. 617-622.

Research output: Contribution to journalArticle

Arbab, Ali Syed ; Koizumi, K. ; Toyama, K. ; Arai, T. ; Araki, T. / Dynamic SPET parameters of 123I-MIBG cardiac imaging. In: Nuclear Medicine Communications. 1999 ; Vol. 20, No. 7. pp. 617-622.
@article{2b9fa57aa040482787b8e5537b04b8e0,
title = "Dynamic SPET parameters of 123I-MIBG cardiac imaging",
abstract = "Early dynamic and late 123I-MIBG SPET studies were performed to investigate several parameters used to distinguish the characteristics of various cardiac disorders. Forty-six individuals (34 non-diabetic, 12 diabetic) with or without heart disease were included in the study. Early dynamic and late static SPET images were acquired using a triple-headed gamma camera. After selecting mid-sections from vertical (VLA) and horizontal (HLA) long-axis images, regions of interest were created over the apex, whole heart and anterior, inferior, septal and lateral walls of the heart. Various uptake ratios at 3,11 and 19 min and 4 h after injection (HU3, HU11, HU19, DUP) and clearances (Kse: between HU3 and HU11; Ke: between HU11 and HU19; Kd: between HU19 and DUP) were calculated. There were significant differences among various cardiac pathologies on the delayed images. Cardiomyopathy patients showed the lowest uptake on the delayed images. When all segments in normal patients and all involved segments in myocardial infarcted patients were compared, there was significantly lower uptake of MIBG in infarcted segments at all time points. Kd showed the lowest value compared with and Ke. In cardiomyopathy patients, Kse, and Kd were significantly different from each other. Both Kse and Ke were significantly higher in cardiomyopathy patients than in normal patients. In conclusion, the results of this study are in line with published data and precise measurement of uptaKe and clearance was possible when excluding background and blood pool activity.",
author = "Arbab, {Ali Syed} and K. Koizumi and K. Toyama and T. Arai and T. Araki",
year = "1999",
month = "1",
day = "1",
doi = "10.1080/00006231-199907000-00004",
language = "English (US)",
volume = "20",
pages = "617--622",
journal = "Nuclear Medicine Communications",
issn = "0143-3636",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Dynamic SPET parameters of 123I-MIBG cardiac imaging

AU - Arbab, Ali Syed

AU - Koizumi, K.

AU - Toyama, K.

AU - Arai, T.

AU - Araki, T.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - Early dynamic and late 123I-MIBG SPET studies were performed to investigate several parameters used to distinguish the characteristics of various cardiac disorders. Forty-six individuals (34 non-diabetic, 12 diabetic) with or without heart disease were included in the study. Early dynamic and late static SPET images were acquired using a triple-headed gamma camera. After selecting mid-sections from vertical (VLA) and horizontal (HLA) long-axis images, regions of interest were created over the apex, whole heart and anterior, inferior, septal and lateral walls of the heart. Various uptake ratios at 3,11 and 19 min and 4 h after injection (HU3, HU11, HU19, DUP) and clearances (Kse: between HU3 and HU11; Ke: between HU11 and HU19; Kd: between HU19 and DUP) were calculated. There were significant differences among various cardiac pathologies on the delayed images. Cardiomyopathy patients showed the lowest uptake on the delayed images. When all segments in normal patients and all involved segments in myocardial infarcted patients were compared, there was significantly lower uptake of MIBG in infarcted segments at all time points. Kd showed the lowest value compared with and Ke. In cardiomyopathy patients, Kse, and Kd were significantly different from each other. Both Kse and Ke were significantly higher in cardiomyopathy patients than in normal patients. In conclusion, the results of this study are in line with published data and precise measurement of uptaKe and clearance was possible when excluding background and blood pool activity.

AB - Early dynamic and late 123I-MIBG SPET studies were performed to investigate several parameters used to distinguish the characteristics of various cardiac disorders. Forty-six individuals (34 non-diabetic, 12 diabetic) with or without heart disease were included in the study. Early dynamic and late static SPET images were acquired using a triple-headed gamma camera. After selecting mid-sections from vertical (VLA) and horizontal (HLA) long-axis images, regions of interest were created over the apex, whole heart and anterior, inferior, septal and lateral walls of the heart. Various uptake ratios at 3,11 and 19 min and 4 h after injection (HU3, HU11, HU19, DUP) and clearances (Kse: between HU3 and HU11; Ke: between HU11 and HU19; Kd: between HU19 and DUP) were calculated. There were significant differences among various cardiac pathologies on the delayed images. Cardiomyopathy patients showed the lowest uptake on the delayed images. When all segments in normal patients and all involved segments in myocardial infarcted patients were compared, there was significantly lower uptake of MIBG in infarcted segments at all time points. Kd showed the lowest value compared with and Ke. In cardiomyopathy patients, Kse, and Kd were significantly different from each other. Both Kse and Ke were significantly higher in cardiomyopathy patients than in normal patients. In conclusion, the results of this study are in line with published data and precise measurement of uptaKe and clearance was possible when excluding background and blood pool activity.

UR - http://www.scopus.com/inward/record.url?scp=0032781850&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032781850&partnerID=8YFLogxK

U2 - 10.1080/00006231-199907000-00004

DO - 10.1080/00006231-199907000-00004

M3 - Article

VL - 20

SP - 617

EP - 622

JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

SN - 0143-3636

IS - 7

ER -