Dysregulation of lipid and cholesterol metabolism in high fat diet fed hyperlipidemic rats: Protective effect of Sida rhomboidea. roxb leaf extract

Menaka Thounaojam, Ravirajsinh Jadeja, Ansarullah, Ranjitsinh Devkar, A. V. Ramachandran

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The present study was undertaken to evaluate the efficacy of freeze dried extract of Sida rhomboidea.roxb leaves (FESR) on alteration in lipid and cholesterol metabolism in high fat diet induced hyperlipidemia in experimental rats. Plasma and hepatic lipid profiles, lipid and cholesterol metabolizing enzymes in target tissues and fecal total lipids and bile acid contents were evaluated in FESR treated normolipidemic and hyperlipidemic rats. These results were compared with synthetic hypolipidemic drug lovastatin (LVS). Results indicate that FESR was able to positively regulate induced experimental hyperlipidemia by significant alteration in plasma and tissue lipid profiles. These results can be attributed to reduced absorption, effective elimination and augmented catabolism of lipids and cholesterol possibly due to high content of saponin and phytosterols in S. Rhomboidea. roxb (SR). Use of SR extract as a potential therapeutic agent against hyperlipidemia is indicated.

Original languageEnglish (US)
Pages (from-to)413-420
Number of pages8
JournalJournal of Health Science
Volume55
Issue number3
DOIs
StatePublished - Jun 1 2009

Fingerprint

High Fat Diet
Nutrition
Lipid Metabolism
Metabolism
Rats
Fats
Cholesterol
Lipids
Hyperlipidemias
Hypolipidemic Agents
Phytosterols
Lovastatin
Tissue
Saponins
Plasmas
Bile Acids and Salts
Liver
Enzymes

Keywords

  • Hypercholesterolemia
  • Hyperlipidemia
  • Sida rhomboidea. roxb

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Dysregulation of lipid and cholesterol metabolism in high fat diet fed hyperlipidemic rats : Protective effect of Sida rhomboidea. roxb leaf extract. / Thounaojam, Menaka; Jadeja, Ravirajsinh; Ansarullah; Devkar, Ranjitsinh; Ramachandran, A. V.

In: Journal of Health Science, Vol. 55, No. 3, 01.06.2009, p. 413-420.

Research output: Contribution to journalArticle

@article{cd20709331554ba5a95e5e3b817017b5,
title = "Dysregulation of lipid and cholesterol metabolism in high fat diet fed hyperlipidemic rats: Protective effect of Sida rhomboidea. roxb leaf extract",
abstract = "The present study was undertaken to evaluate the efficacy of freeze dried extract of Sida rhomboidea.roxb leaves (FESR) on alteration in lipid and cholesterol metabolism in high fat diet induced hyperlipidemia in experimental rats. Plasma and hepatic lipid profiles, lipid and cholesterol metabolizing enzymes in target tissues and fecal total lipids and bile acid contents were evaluated in FESR treated normolipidemic and hyperlipidemic rats. These results were compared with synthetic hypolipidemic drug lovastatin (LVS). Results indicate that FESR was able to positively regulate induced experimental hyperlipidemia by significant alteration in plasma and tissue lipid profiles. These results can be attributed to reduced absorption, effective elimination and augmented catabolism of lipids and cholesterol possibly due to high content of saponin and phytosterols in S. Rhomboidea. roxb (SR). Use of SR extract as a potential therapeutic agent against hyperlipidemia is indicated.",
keywords = "Hypercholesterolemia, Hyperlipidemia, Sida rhomboidea. roxb",
author = "Menaka Thounaojam and Ravirajsinh Jadeja and Ansarullah and Ranjitsinh Devkar and Ramachandran, {A. V.}",
year = "2009",
month = "6",
day = "1",
doi = "10.1248/jhs.55.413",
language = "English (US)",
volume = "55",
pages = "413--420",
journal = "Journal of Health Science",
issn = "1344-9702",
publisher = "Pharmaceutical Society of Japan",
number = "3",

}

TY - JOUR

T1 - Dysregulation of lipid and cholesterol metabolism in high fat diet fed hyperlipidemic rats

T2 - Protective effect of Sida rhomboidea. roxb leaf extract

AU - Thounaojam, Menaka

AU - Jadeja, Ravirajsinh

AU - Ansarullah,

AU - Devkar, Ranjitsinh

AU - Ramachandran, A. V.

PY - 2009/6/1

Y1 - 2009/6/1

N2 - The present study was undertaken to evaluate the efficacy of freeze dried extract of Sida rhomboidea.roxb leaves (FESR) on alteration in lipid and cholesterol metabolism in high fat diet induced hyperlipidemia in experimental rats. Plasma and hepatic lipid profiles, lipid and cholesterol metabolizing enzymes in target tissues and fecal total lipids and bile acid contents were evaluated in FESR treated normolipidemic and hyperlipidemic rats. These results were compared with synthetic hypolipidemic drug lovastatin (LVS). Results indicate that FESR was able to positively regulate induced experimental hyperlipidemia by significant alteration in plasma and tissue lipid profiles. These results can be attributed to reduced absorption, effective elimination and augmented catabolism of lipids and cholesterol possibly due to high content of saponin and phytosterols in S. Rhomboidea. roxb (SR). Use of SR extract as a potential therapeutic agent against hyperlipidemia is indicated.

AB - The present study was undertaken to evaluate the efficacy of freeze dried extract of Sida rhomboidea.roxb leaves (FESR) on alteration in lipid and cholesterol metabolism in high fat diet induced hyperlipidemia in experimental rats. Plasma and hepatic lipid profiles, lipid and cholesterol metabolizing enzymes in target tissues and fecal total lipids and bile acid contents were evaluated in FESR treated normolipidemic and hyperlipidemic rats. These results were compared with synthetic hypolipidemic drug lovastatin (LVS). Results indicate that FESR was able to positively regulate induced experimental hyperlipidemia by significant alteration in plasma and tissue lipid profiles. These results can be attributed to reduced absorption, effective elimination and augmented catabolism of lipids and cholesterol possibly due to high content of saponin and phytosterols in S. Rhomboidea. roxb (SR). Use of SR extract as a potential therapeutic agent against hyperlipidemia is indicated.

KW - Hypercholesterolemia

KW - Hyperlipidemia

KW - Sida rhomboidea. roxb

UR - http://www.scopus.com/inward/record.url?scp=66749109214&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66749109214&partnerID=8YFLogxK

U2 - 10.1248/jhs.55.413

DO - 10.1248/jhs.55.413

M3 - Article

AN - SCOPUS:66749109214

VL - 55

SP - 413

EP - 420

JO - Journal of Health Science

JF - Journal of Health Science

SN - 1344-9702

IS - 3

ER -