E-Cadherin Engagement Stimulates Tyrosine Phosphorylation

Michael S. Kinch, Leslie Anne Petch Lee, Cuiling Zhong, Keith Burridge

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Cadherins are cell adhesion molecules concentrated at intercellular adherens junctions, where they form a multiprotein complex with cytoplasmic catenins. Although cell-cell interactions affect many aspects of cell behavior, little is known about signaling pathways triggered by cadherin engagement. We show here that E-cadherin-mediated cell-cell adhesion leads to a rapid increase in tyrosine phosphorylation at sites of cell-cell contact and that this stimulation of tyrosine phosphorylation can be mimicked by aggregation of E-cadherin with antibodies. The proteins that become phosphorylated are distinct from those previously shown to be tyrosine phosphorylated in response to integrin-mediated adhesion and include ras-GAP. We also find that E-cadherin-mediated tyrosine phosphorylation is not required for the assembly of adherens-type junctions.

Original languageEnglish (US)
Pages (from-to)425-437
Number of pages13
JournalCell Communication and Adhesion
Volume4
Issue number6
StatePublished - Dec 1 1997
Externally publishedYes

Fingerprint

Phosphorylation
Cadherins
Tyrosine
Adherens Junctions
ras GTPase-Activating Proteins
Multiprotein Complexes
Catenins
Intercellular Junctions
Cell adhesion
Cell Adhesion Molecules
Cell Adhesion
Integrins
Cell Communication
Adhesion
Agglomeration
Antibodies
Proteins

Keywords

  • E-cadherin
  • Tyrosine phosphorylation

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

Cite this

Kinch, M. S., Petch Lee, L. A., Zhong, C., & Burridge, K. (1997). E-Cadherin Engagement Stimulates Tyrosine Phosphorylation. Cell Communication and Adhesion, 4(6), 425-437.

E-Cadherin Engagement Stimulates Tyrosine Phosphorylation. / Kinch, Michael S.; Petch Lee, Leslie Anne; Zhong, Cuiling; Burridge, Keith.

In: Cell Communication and Adhesion, Vol. 4, No. 6, 01.12.1997, p. 425-437.

Research output: Contribution to journalArticle

Kinch, MS, Petch Lee, LA, Zhong, C & Burridge, K 1997, 'E-Cadherin Engagement Stimulates Tyrosine Phosphorylation', Cell Communication and Adhesion, vol. 4, no. 6, pp. 425-437.
Kinch MS, Petch Lee LA, Zhong C, Burridge K. E-Cadherin Engagement Stimulates Tyrosine Phosphorylation. Cell Communication and Adhesion. 1997 Dec 1;4(6):425-437.
Kinch, Michael S. ; Petch Lee, Leslie Anne ; Zhong, Cuiling ; Burridge, Keith. / E-Cadherin Engagement Stimulates Tyrosine Phosphorylation. In: Cell Communication and Adhesion. 1997 ; Vol. 4, No. 6. pp. 425-437.
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