E-Cadherin Engagement Stimulates Tyrosine Phosphorylation

Michael S. Kinch, Leslie Petch, Cuiling Zhong, Keith Burridge

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Cadherins are cell adhesion molecules concentrated at intercellular adherens junctions, where they form a multiprotein complex with cytoplasmic catenins. Although cell-cell interactions affect many aspects of cell behavior, little is known about signaling pathways triggered by cadherin engagement. We show here that E-cadherin-mediated cell-cell adhesion leads to a rapid increase in tyrosine phosphorylation at sites of cell-cell contact and that this stimulation of tyrosine phosphorylation can be mimicked by aggregation of E-cadherin with antibodies. The proteins that become phosphorylated are distinct from those previously shown to be tyrosine phosphorylated in response to integrin-mediated adhesion and include ras-GAP. We also find that E-cadherin-mediated tyrosine phosphorylation is not required for the assembly of adherens-type junctions.

Original languageEnglish (US)
Pages (from-to)425-437
Number of pages13
JournalCell Communication and Adhesion
Volume4
Issue number6
DOIs
StatePublished - 1997

Keywords

  • E-cadherin
  • Tyrosine phosphorylation

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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