Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995: Determinants of survival

Ramses F. Sadek, Ali S. Khan, Gary Stevens, C. J. Peters, Thomas G. Ksiazek

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

In May 1995, an international team characterized and contained an outbreak of Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo. This study reports the descriptive features of this outbreak along with a statistical analysis of the outbreak data. Proportional hazards analysis was used to examine the effect of age, phase of the outbreak, and sex on the risk of death, and a conditional probability analysis was used to examine the effectiveness of whole blood transfusion from convalescent patients on survival. Two hundred fifty case-patients (80.7%) died. The main predictor of survival in the proportional hazards model was age. No statistical evidence of a survival benefit of transfusion of blood from convalescent patients was evident after adjusting for age, sex, and the days since onset of symptoms (P = .1713).

Original languageEnglish (US)
Pages (from-to)S24-S27
JournalJournal of Infectious Diseases
Volume179
Issue numberSUPPL. 1
DOIs
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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