Effect of a Calcium Sulfate Implant with Calcium Sulfate Barrier on Periodontal Healing in 3-Wall Intrabony Defects in Dogs

Chong Kwan Kim, Hyun Young Kim, Jung Kiu Chai, Kyoo Sung Cho, Ik Sang Moon, Seong Ho Choi, John S. Sottosanti, Ulf M E Wikesjö

Research output: Contribution to journalArticle

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Abstract

THIS CONTROLLED, SPLIT-MOUTH, PRECLINICAL STUDY was designed to evaluate outcome following surgical implantation of an allogeneic, freeze-dried demineralized bone matrix-calcium sulfate (DBM+CS) composite with a CS barrier in 3-wall intrabony periodontal defects in 4 dogs. Control conditions included surgical implantation of DBM or CS and gingival flap surgery (GFS) alone. Three-wall intrabony defects (4X4X4 mm) were surgically created at the mesial and distal aspect of the maxillary and mandibular first and third premolars, respectively. Maxillary and mandibular defects each received 1 of the 4 experimental conditions. Experimental conditions were rotated between defect sites in subsequent animals. Block sections of the defects were collected at sacrifice 8 weeks postsurgery and processed for histometric analysis. Histometric defect height (means ± SD) for the DBM+CS, DBM, CS, and GFS groups amounted to 4.2 ± 0.5, 4.3 ± 0.7, 4.0 ± 0.2, and 4.1 ± 0.2 mm, respectively. Connective tissue adhesion (connective tissue contact to the root without apparent cementum formation) amounted to 0.4 ± 0.3, 0.4 ± 0.3, 0.5 ± 0.2, and 1.6 ± 0.5 mm for the DBM+CS, DBM, CS, and GFS groups, respectively; the DBM+CS, DBM, and CS groups being significantly different from the GFS group (P < 0.05). Cementum regeneration amounted to 3.0 ± 0.3, 3.1 ± 0.4, 2.5 ± 0.4, and 1.6 ± 0.3 mm for the DBM+CS, DBM, CS, and GFS groups, respectively; the DBM+CS, DBM, and CS groups being significantly different from the GFS group (P < 0.05). Alveolar bone regeneration amounted to 2.7 ± 0.4, 2.7 ± 0.3, 1.8 ± 0.5, and 0.7 ± 0.1 mm for the DBM+CS, DBM, CS, and GFS groups, respectively; the DBM+CS, DBM, and CS groups being different from the GFS group (P < 0.05), and the DBM+CS and DBM groups being different from the CS group (P < 0.05). None of the DBM-containing implants provided evidence of bone metabolic activity. In summary, surgical implantation of DBM and CS, alone or in combination, may result in significantly improved regeneration of alveolar bone and cementum in this preclinical model. Observed regeneration is likely unrelated to a biologic activity inherent in DBM. Rather it appears that space-providing properties of the implants supported observed regeneration.

Original languageEnglish (US)
Pages (from-to)982-988
Number of pages7
JournalJournal of Periodontology
Volume69
Issue number9
DOIs
StatePublished - Jan 1 1998

Fingerprint

Calcium Sulfate
Dogs
Dental Cementum
Regeneration
Bone Regeneration
Connective Tissue
Tissue Adhesions
Bone Matrix
Bicuspid
Mouth
Bone and Bones

Keywords

  • Animal studies
  • Bone regeneration
  • Bone, demineralized
  • Bone, freeze-dried
  • Calcium sulfate
  • Periodontal attachment
  • Periodontal diseases/therapy
  • Periodontal regeneration

ASJC Scopus subject areas

  • Periodontics

Cite this

Kim, C. K., Kim, H. Y., Chai, J. K., Cho, K. S., Moon, I. S., Choi, S. H., ... Wikesjö, U. M. E. (1998). Effect of a Calcium Sulfate Implant with Calcium Sulfate Barrier on Periodontal Healing in 3-Wall Intrabony Defects in Dogs. Journal of Periodontology, 69(9), 982-988. https://doi.org/10.1902/jop.1998.69.9.982

Effect of a Calcium Sulfate Implant with Calcium Sulfate Barrier on Periodontal Healing in 3-Wall Intrabony Defects in Dogs. / Kim, Chong Kwan; Kim, Hyun Young; Chai, Jung Kiu; Cho, Kyoo Sung; Moon, Ik Sang; Choi, Seong Ho; Sottosanti, John S.; Wikesjö, Ulf M E.

In: Journal of Periodontology, Vol. 69, No. 9, 01.01.1998, p. 982-988.

Research output: Contribution to journalArticle

Kim, CK, Kim, HY, Chai, JK, Cho, KS, Moon, IS, Choi, SH, Sottosanti, JS & Wikesjö, UME 1998, 'Effect of a Calcium Sulfate Implant with Calcium Sulfate Barrier on Periodontal Healing in 3-Wall Intrabony Defects in Dogs', Journal of Periodontology, vol. 69, no. 9, pp. 982-988. https://doi.org/10.1902/jop.1998.69.9.982
Kim, Chong Kwan ; Kim, Hyun Young ; Chai, Jung Kiu ; Cho, Kyoo Sung ; Moon, Ik Sang ; Choi, Seong Ho ; Sottosanti, John S. ; Wikesjö, Ulf M E. / Effect of a Calcium Sulfate Implant with Calcium Sulfate Barrier on Periodontal Healing in 3-Wall Intrabony Defects in Dogs. In: Journal of Periodontology. 1998 ; Vol. 69, No. 9. pp. 982-988.
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T1 - Effect of a Calcium Sulfate Implant with Calcium Sulfate Barrier on Periodontal Healing in 3-Wall Intrabony Defects in Dogs

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AU - Kim, Hyun Young

AU - Chai, Jung Kiu

AU - Cho, Kyoo Sung

AU - Moon, Ik Sang

AU - Choi, Seong Ho

AU - Sottosanti, John S.

AU - Wikesjö, Ulf M E

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N2 - THIS CONTROLLED, SPLIT-MOUTH, PRECLINICAL STUDY was designed to evaluate outcome following surgical implantation of an allogeneic, freeze-dried demineralized bone matrix-calcium sulfate (DBM+CS) composite with a CS barrier in 3-wall intrabony periodontal defects in 4 dogs. Control conditions included surgical implantation of DBM or CS and gingival flap surgery (GFS) alone. Three-wall intrabony defects (4X4X4 mm) were surgically created at the mesial and distal aspect of the maxillary and mandibular first and third premolars, respectively. Maxillary and mandibular defects each received 1 of the 4 experimental conditions. Experimental conditions were rotated between defect sites in subsequent animals. Block sections of the defects were collected at sacrifice 8 weeks postsurgery and processed for histometric analysis. Histometric defect height (means ± SD) for the DBM+CS, DBM, CS, and GFS groups amounted to 4.2 ± 0.5, 4.3 ± 0.7, 4.0 ± 0.2, and 4.1 ± 0.2 mm, respectively. Connective tissue adhesion (connective tissue contact to the root without apparent cementum formation) amounted to 0.4 ± 0.3, 0.4 ± 0.3, 0.5 ± 0.2, and 1.6 ± 0.5 mm for the DBM+CS, DBM, CS, and GFS groups, respectively; the DBM+CS, DBM, and CS groups being significantly different from the GFS group (P < 0.05). Cementum regeneration amounted to 3.0 ± 0.3, 3.1 ± 0.4, 2.5 ± 0.4, and 1.6 ± 0.3 mm for the DBM+CS, DBM, CS, and GFS groups, respectively; the DBM+CS, DBM, and CS groups being significantly different from the GFS group (P < 0.05). Alveolar bone regeneration amounted to 2.7 ± 0.4, 2.7 ± 0.3, 1.8 ± 0.5, and 0.7 ± 0.1 mm for the DBM+CS, DBM, CS, and GFS groups, respectively; the DBM+CS, DBM, and CS groups being different from the GFS group (P < 0.05), and the DBM+CS and DBM groups being different from the CS group (P < 0.05). None of the DBM-containing implants provided evidence of bone metabolic activity. In summary, surgical implantation of DBM and CS, alone or in combination, may result in significantly improved regeneration of alveolar bone and cementum in this preclinical model. Observed regeneration is likely unrelated to a biologic activity inherent in DBM. Rather it appears that space-providing properties of the implants supported observed regeneration.

AB - THIS CONTROLLED, SPLIT-MOUTH, PRECLINICAL STUDY was designed to evaluate outcome following surgical implantation of an allogeneic, freeze-dried demineralized bone matrix-calcium sulfate (DBM+CS) composite with a CS barrier in 3-wall intrabony periodontal defects in 4 dogs. Control conditions included surgical implantation of DBM or CS and gingival flap surgery (GFS) alone. Three-wall intrabony defects (4X4X4 mm) were surgically created at the mesial and distal aspect of the maxillary and mandibular first and third premolars, respectively. Maxillary and mandibular defects each received 1 of the 4 experimental conditions. Experimental conditions were rotated between defect sites in subsequent animals. Block sections of the defects were collected at sacrifice 8 weeks postsurgery and processed for histometric analysis. Histometric defect height (means ± SD) for the DBM+CS, DBM, CS, and GFS groups amounted to 4.2 ± 0.5, 4.3 ± 0.7, 4.0 ± 0.2, and 4.1 ± 0.2 mm, respectively. Connective tissue adhesion (connective tissue contact to the root without apparent cementum formation) amounted to 0.4 ± 0.3, 0.4 ± 0.3, 0.5 ± 0.2, and 1.6 ± 0.5 mm for the DBM+CS, DBM, CS, and GFS groups, respectively; the DBM+CS, DBM, and CS groups being significantly different from the GFS group (P < 0.05). Cementum regeneration amounted to 3.0 ± 0.3, 3.1 ± 0.4, 2.5 ± 0.4, and 1.6 ± 0.3 mm for the DBM+CS, DBM, CS, and GFS groups, respectively; the DBM+CS, DBM, and CS groups being significantly different from the GFS group (P < 0.05). Alveolar bone regeneration amounted to 2.7 ± 0.4, 2.7 ± 0.3, 1.8 ± 0.5, and 0.7 ± 0.1 mm for the DBM+CS, DBM, CS, and GFS groups, respectively; the DBM+CS, DBM, and CS groups being different from the GFS group (P < 0.05), and the DBM+CS and DBM groups being different from the CS group (P < 0.05). None of the DBM-containing implants provided evidence of bone metabolic activity. In summary, surgical implantation of DBM and CS, alone or in combination, may result in significantly improved regeneration of alveolar bone and cementum in this preclinical model. Observed regeneration is likely unrelated to a biologic activity inherent in DBM. Rather it appears that space-providing properties of the implants supported observed regeneration.

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