Effect of Anteroventral Third Ventricle Lesions on Vascular Sodium-Pump Activity in Two-Kidney Goldblatt Hypertension

Emel Songu-Mize, Steve L. Bealer, Robert William Caldwell

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

We studied the effects of anteroventral third ventricle (AV3V) lesions on the vascular Na+-pump activity and blood pressure of rats prepared by the two-kidney Goldblatt procedure. Blood pressures and Na+-pump activity of the isolated tail arteries, measured as ouabain-sensitive86Rb+- uptake, were determined in rats with renal artery clips, rats with AV3V lesions, and rats with AV3V lesions. Rats with renal artery clips developed higher blood pressures (40%) and higher vascular Na+- pump activity (20%-35%) than rats with no renal clips. Placement of AV3V lesions prior to the placement of renal clips prevented the increase in blood pressure and the increase in vascular Na+- pump activity. Plasma potassium and creatinine concentrations, nonspecific86Rb+-uptake, and hematocrit were not different among these groups. Plasma sodium concentration was elevated in the AV3V lesioned control group. These experiments suggest a possible role of this CNS region in the regulation of vascular Na+-pump function during hypertensive states.

Original languageEnglish (US)
Pages (from-to)I-89-I-93
JournalHypertension
Volume5
Issue number2
DOIs
StatePublished - 1983
Externally publishedYes

Keywords

  • AV3V lesion
  • Na-pump activity
  • One clip Goldblatt hypertension
  • Rb-uptake
  • Renal artery clips
  • Tail artery
  • Two-kidney

ASJC Scopus subject areas

  • Internal Medicine

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