Effect of bisphosphonates and gallium on dentin resorption in vitro

F. R. Liewehr, D. W. Craft, P. D. Primack, J. C. Kulild, D. K. Turgeon, D. E. Sutherland, G. S. Schuster, D. H. Pashley

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Abstract Replacement resorption may follow the replantation of an avulsed tooth. Currently there is no effective treatment for replacement resorption. The purpose of this study was to investigate the effect of bisphosphonates and gallium nitrate, which have been shown to reduce bone resorption, on cells which resorb dentin. Osteoclast‐like cells were obtained by culturing cells from prenatal chick tibeas. These cells were seeded onto slices of human dentin which had been soaked in either saline (control), or solutions of 10–5 M 1‐hydroxyethylidene‐1, 1‐bisphosphonic acid (EHBP), 10–6 M dichloromethylene bisphosphonic acid (Cl2MBP), or 10–6 M gallium nitrate. Resorption was measured by counting the number of resorptive lacunae produced by the cells. Results indicated that the experimental groups did not differ significantly from each other, but each exhibited significantly reduced resorption compared with saline controls (p<0.01). These results suggested that the experimental treatment reduced dentinal resorption by the osteoclast‐like cells, and that these agents might be useful to prevent or at least postpone replacement resorption in avulsed teeth.

Original languageEnglish (US)
Pages (from-to)20-26
Number of pages7
JournalDental Traumatology
Volume11
Issue number1
DOIs
StatePublished - Feb 1995

Fingerprint

Gallium
Diphosphonates
Dentin
gallium nitrate
Tooth Avulsion
Acids
Replantation
Bone Resorption
In Vitro Techniques

Keywords

  • pyrophosphate
  • root resorption
  • tooth avulsion
  • tooth replantation

ASJC Scopus subject areas

  • Oral Surgery

Cite this

Liewehr, F. R., Craft, D. W., Primack, P. D., Kulild, J. C., Turgeon, D. K., Sutherland, D. E., ... Pashley, D. H. (1995). Effect of bisphosphonates and gallium on dentin resorption in vitro. Dental Traumatology, 11(1), 20-26. https://doi.org/10.1111/j.1600-9657.1995.tb00674.x

Effect of bisphosphonates and gallium on dentin resorption in vitro. / Liewehr, F. R.; Craft, D. W.; Primack, P. D.; Kulild, J. C.; Turgeon, D. K.; Sutherland, D. E.; Schuster, G. S.; Pashley, D. H.

In: Dental Traumatology, Vol. 11, No. 1, 02.1995, p. 20-26.

Research output: Contribution to journalArticle

Liewehr, FR, Craft, DW, Primack, PD, Kulild, JC, Turgeon, DK, Sutherland, DE, Schuster, GS & Pashley, DH 1995, 'Effect of bisphosphonates and gallium on dentin resorption in vitro', Dental Traumatology, vol. 11, no. 1, pp. 20-26. https://doi.org/10.1111/j.1600-9657.1995.tb00674.x
Liewehr FR, Craft DW, Primack PD, Kulild JC, Turgeon DK, Sutherland DE et al. Effect of bisphosphonates and gallium on dentin resorption in vitro. Dental Traumatology. 1995 Feb;11(1):20-26. https://doi.org/10.1111/j.1600-9657.1995.tb00674.x
Liewehr, F. R. ; Craft, D. W. ; Primack, P. D. ; Kulild, J. C. ; Turgeon, D. K. ; Sutherland, D. E. ; Schuster, G. S. ; Pashley, D. H. / Effect of bisphosphonates and gallium on dentin resorption in vitro. In: Dental Traumatology. 1995 ; Vol. 11, No. 1. pp. 20-26.
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