Effect of catecholamines on pulmonary circulation at elevated vascular tone

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The effect of catecholamine stimulation on the longitudinal resistance and compliance distribution in the canine pulmonary vasculature was evaluated under control vascular tone and after vascular tone was elevated using the thromboxane analogue U-46619. The arterial-, venous-, and double-occlusion techniques were used to measure the segmental resistances and compliances in isolated dog lung blood perfused at constant flow. The results of this study indicate that at control vascular tone the catecholamines norepinephrine and epinephrine increase pulmonary vascular resistance and decrease pulmonary vascular compliance through α1- and α2-receptor-mediated stimulation with precapillary α1- and α2-receptors and postcapillary α2-receptors interacting with precapillary and postcapillary β2-receptors. In addition, epinephrine appears to have a greater effect on β2-receptors than norepinephrine. When vascular tone was elevated, the effect of norepinephrine and epinephrine on pulmonary vascular resistance was not present, which may be due to the appearance of a more pronounced vasodilatory β2-receptor system and an attenuation of the α-mediated vasoconstrictor responses. In addition, neither catecholamine had any significant effect on pulmonary vascular compliance when vascular tone was raised. These data suggest that the adrenergic-receptor systems modulating pulmonary vascular resistance and compliance in the canine pulmonary circulation are altered when vascular tone is elevated. As a result, these altered pulmonary vascular responses may affect pulmonary capillary pressure, a major determinant of lung fluid balance.

Original languageEnglish (US)
Pages (from-to)1452-1458
Number of pages7
JournalJournal of Applied Physiology
Volume78
Issue number4
DOIs
StatePublished - Jan 1 1995

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Pulmonary Circulation
Catecholamines
Blood Vessels
Lung
Vascular Resistance
Epinephrine
Compliance
Lung Compliance
Adrenergic Receptors
Canidae
Norepinephrine
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Water-Electrolyte Balance
Thromboxanes
Vasoconstrictor Agents
Dogs
Pressure

Keywords

  • prazosin
  • pulmonary capillary pressure
  • pulmonary segmental vascular compliance
  • pulmonary segmental vascular resistance
  • yohimbine
  • α- adrenoceptors
  • β-adrenoceptors

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Effect of catecholamines on pulmonary circulation at elevated vascular tone. / Barman, Scott A.

In: Journal of Applied Physiology, Vol. 78, No. 4, 01.01.1995, p. 1452-1458.

Research output: Contribution to journalArticle

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