Effect of Chronic Hypoxia on Angiotensin-lnduced Pulmonary Vasoconstriction and Converting Enzyme Activity in the Rat1

Robert W. Caldwell, Clark M. Blatteis

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Rats were exposed to high-altitude (5500 m) hypoxia for 2 weeks. On examination 1-3 days after return to sea level and compared with control rats, they exhibited pulmonary hypertension, reduced angiotensin-converting enzyme activity, greater vascular responsiveness to angiotensin II (AII), and resistance to blockade of AII pulmonary pressor responses by the AII antagonist, saralasin.

Original languageEnglish (US)
Pages (from-to)346-350
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume172
Issue number3
DOIs
StatePublished - Mar 1983

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Angiotensins
Enzyme activity
Vasoconstriction
Angiotensin II
Lung
Enzymes
Rat control
Saralasin
Sea level
Peptidyl-Dipeptidase A
Pulmonary Hypertension
Oceans and Seas
Blood Vessels
Rats
Hypoxia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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