Abstract
Rats were exposed to high-altitude (5500 m) hypoxia for 2 weeks. On examination 1-3 days after return to sea level and compared with control rats, they exhibited pulmonary hypertension, reduced angiotensin-converting enzyme activity, greater vascular responsiveness to angiotensin II (AII), and resistance to blockade of AII pulmonary pressor responses by the AII antagonist, saralasin.
Original language | English (US) |
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Pages (from-to) | 346-350 |
Number of pages | 5 |
Journal | Proceedings of the Society for Experimental Biology and Medicine |
Volume | 172 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1983 |
Externally published | Yes |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology