Effect of chronic sulfonylurea treatment on the myocardium of insulin-dependent diabetic rats

Mahmood S Mozaffari, G. L. Wilson, S. W. Schaffer

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Adult rats treated with high doses of streptozocin became progressively more hyperglycemic during the first month of the diabetic condition. Treatment of these rats with the sulfonylurea glyburide halted, and in some cases, reversed this process in a high percentage of the diabetics. Associated with the glyburide-mediated improvement in fasting blood glucose levels was an increase in myocardial glucose utilization and lactate production. The stimulation of myocardial glucose utilization by insulin was greater in glyburide-treated hearts, indicating that the hyperglycemic agent increased insulin responsiveness. The sulfonylurea also partially restored insulin sensitivity to the normal range. In agreement with previous studies, myocardial mechanical function was significantly impaired in the diabetic heart. When treated with glyburide, the severity of the mechanical defect was significantly less. The sulfonylurea also promoted an increase in myosin ATPase activity and a shift in the myosin isozyme pattern in favour of the most active V1 form. These results imply that glyburide therapy can provide benefit to the diabetic heart by improving energy metabolism and promoting a shift in myosin towards the most active form.

Original languageEnglish (US)
Pages (from-to)1481-1486
Number of pages6
JournalCanadian Journal of Physiology and Pharmacology
Volume66
Issue number12
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Glyburide
Myocardium
Insulin
Myosins
Glucose
Streptozocin
Energy Metabolism
Isoenzymes
Insulin Resistance
Blood Glucose
Lactic Acid
Fasting
Reference Values

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

Effect of chronic sulfonylurea treatment on the myocardium of insulin-dependent diabetic rats. / Mozaffari, Mahmood S; Wilson, G. L.; Schaffer, S. W.

In: Canadian Journal of Physiology and Pharmacology, Vol. 66, No. 12, 01.01.1988, p. 1481-1486.

Research output: Contribution to journalArticle

@article{55ff37be877141e99d0e4044275222c5,
title = "Effect of chronic sulfonylurea treatment on the myocardium of insulin-dependent diabetic rats",
abstract = "Adult rats treated with high doses of streptozocin became progressively more hyperglycemic during the first month of the diabetic condition. Treatment of these rats with the sulfonylurea glyburide halted, and in some cases, reversed this process in a high percentage of the diabetics. Associated with the glyburide-mediated improvement in fasting blood glucose levels was an increase in myocardial glucose utilization and lactate production. The stimulation of myocardial glucose utilization by insulin was greater in glyburide-treated hearts, indicating that the hyperglycemic agent increased insulin responsiveness. The sulfonylurea also partially restored insulin sensitivity to the normal range. In agreement with previous studies, myocardial mechanical function was significantly impaired in the diabetic heart. When treated with glyburide, the severity of the mechanical defect was significantly less. The sulfonylurea also promoted an increase in myosin ATPase activity and a shift in the myosin isozyme pattern in favour of the most active V1 form. These results imply that glyburide therapy can provide benefit to the diabetic heart by improving energy metabolism and promoting a shift in myosin towards the most active form.",
author = "Mozaffari, {Mahmood S} and Wilson, {G. L.} and Schaffer, {S. W.}",
year = "1988",
month = "1",
day = "1",
doi = "10.1139/y88-242",
language = "English (US)",
volume = "66",
pages = "1481--1486",
journal = "Canadian Journal of Physiology and Pharmacology",
issn = "0008-4212",
publisher = "National Research Council of Canada",
number = "12",

}

TY - JOUR

T1 - Effect of chronic sulfonylurea treatment on the myocardium of insulin-dependent diabetic rats

AU - Mozaffari, Mahmood S

AU - Wilson, G. L.

AU - Schaffer, S. W.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - Adult rats treated with high doses of streptozocin became progressively more hyperglycemic during the first month of the diabetic condition. Treatment of these rats with the sulfonylurea glyburide halted, and in some cases, reversed this process in a high percentage of the diabetics. Associated with the glyburide-mediated improvement in fasting blood glucose levels was an increase in myocardial glucose utilization and lactate production. The stimulation of myocardial glucose utilization by insulin was greater in glyburide-treated hearts, indicating that the hyperglycemic agent increased insulin responsiveness. The sulfonylurea also partially restored insulin sensitivity to the normal range. In agreement with previous studies, myocardial mechanical function was significantly impaired in the diabetic heart. When treated with glyburide, the severity of the mechanical defect was significantly less. The sulfonylurea also promoted an increase in myosin ATPase activity and a shift in the myosin isozyme pattern in favour of the most active V1 form. These results imply that glyburide therapy can provide benefit to the diabetic heart by improving energy metabolism and promoting a shift in myosin towards the most active form.

AB - Adult rats treated with high doses of streptozocin became progressively more hyperglycemic during the first month of the diabetic condition. Treatment of these rats with the sulfonylurea glyburide halted, and in some cases, reversed this process in a high percentage of the diabetics. Associated with the glyburide-mediated improvement in fasting blood glucose levels was an increase in myocardial glucose utilization and lactate production. The stimulation of myocardial glucose utilization by insulin was greater in glyburide-treated hearts, indicating that the hyperglycemic agent increased insulin responsiveness. The sulfonylurea also partially restored insulin sensitivity to the normal range. In agreement with previous studies, myocardial mechanical function was significantly impaired in the diabetic heart. When treated with glyburide, the severity of the mechanical defect was significantly less. The sulfonylurea also promoted an increase in myosin ATPase activity and a shift in the myosin isozyme pattern in favour of the most active V1 form. These results imply that glyburide therapy can provide benefit to the diabetic heart by improving energy metabolism and promoting a shift in myosin towards the most active form.

UR - http://www.scopus.com/inward/record.url?scp=0024260990&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024260990&partnerID=8YFLogxK

U2 - 10.1139/y88-242

DO - 10.1139/y88-242

M3 - Article

C2 - 3147810

AN - SCOPUS:0024260990

VL - 66

SP - 1481

EP - 1486

JO - Canadian Journal of Physiology and Pharmacology

JF - Canadian Journal of Physiology and Pharmacology

SN - 0008-4212

IS - 12

ER -