Effect of drug-induced taurine depletion on cardiac contractility and metabolism

Mahmood S Mozaffari, Boen H. Tan, Michael A. Lucia, Stephen W. Schaffer

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Myocardial taurine content was halved in rats maintained for 3 weeks on tap water containing either 1% guanidinoethylsulfonate (GES) or 3% β-alanine. The decrease in taurine content did not affect myocardial contraction; however, it significantly altered myocardial metabolism. The major effect of the treatment was a significant stimulation in the rate of glycolysis and lactate production. The rise in glycolytic flux was associated with activation of phosphofructokinase, presumably caused by a decrease in tissue citrate levels. GES-treated hearts also contained slightly lower creatine phosphate content, but since this effect was not observed in the β-alanine-treated hearts, it appeared to be independent of taurine depletion. The consequences of these metabolic changes are discussed.

Original languageEnglish (US)
Pages (from-to)985-989
Number of pages5
JournalBiochemical Pharmacology
Volume35
Issue number6
DOIs
StatePublished - Mar 15 1986
Externally publishedYes

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Taurine
Metabolism
Alanine
Pharmaceutical Preparations
Myocardial Contraction
Phosphofructokinases
Phosphocreatine
Glycolysis
Citric Acid
Rats
Lactic Acid
Chemical activation
Tissue
Fluxes
Water

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

Cite this

Effect of drug-induced taurine depletion on cardiac contractility and metabolism. / Mozaffari, Mahmood S; Tan, Boen H.; Lucia, Michael A.; Schaffer, Stephen W.

In: Biochemical Pharmacology, Vol. 35, No. 6, 15.03.1986, p. 985-989.

Research output: Contribution to journalArticle

Mozaffari, Mahmood S ; Tan, Boen H. ; Lucia, Michael A. ; Schaffer, Stephen W. / Effect of drug-induced taurine depletion on cardiac contractility and metabolism. In: Biochemical Pharmacology. 1986 ; Vol. 35, No. 6. pp. 985-989.
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