Effect of exercise on fluoride metabolism in adult humans: A pilot study

Fatemeh V. Zohoori; Alison Innerd; Liane B. Azevedo; Gary M. Whitford; Anne Maguire

doi:10.1038/srep16905

Effect of exercise on fluoride metabolism in adult humans: A pilot study

Fatemeh V. Zohoori, Alison Innerd, Liane B. Azevedo, Gary M. Whitford, Anne Maguire

Research output: Contribution to journal › Article › peer-review

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Abstract

An understanding of all aspects of fluoride metabolism is critical to identify its biological effects and avoid fluoride toxicity in humans. Fluoride metabolism and subsequently its body retention may be affected by physiological responses to acute exercise. This pilot study investigated the effect of exercise on plasma fluoride concentration, urinary fluoride excretion and fluoride renal clearance following no exercise and three exercise intensity conditions in nine healthy adults after taking a 1-mg Fluoride tablet. After no, light, moderate and vigorous exercise, respectively, the mean (SD) baseline-adjusted i) plasma fluoride concentration was 9.6(6.3), 11.4(6.3), 15.6(7.7) and 14.9(10.0)ng/ml; ii) rate of urinary fluoride excretion over 0-8h was 46(15), 44(22), 34(17) and 36(17)μg/h; and iii) rate of fluoride renal clearance was 26.5(9.0), 27.2(30.4), 13.1(20.4) and 18.3(34.9)ml/min. The observed trend of a rise in plasma fluoride concentration and decline in rate of fluoride renal clearance with increasing exercise intensity needs to be investigated in a larger trial. This study, which provides the first data on the effect of exercise with different intensities on fluoride metabolism in humans, informs sample size planning for any subsequent definitive trial, by providing a robust estimate of the variability of the effect.

Original language	English (US)
Article number	16905
Journal	Scientific reports
Volume	5
DOIs	https://doi.org/10.1038/srep16905
State	Published - Nov 19 2015
Externally published	Yes

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title = "Effect of exercise on fluoride metabolism in adult humans: A pilot study",

abstract = "An understanding of all aspects of fluoride metabolism is critical to identify its biological effects and avoid fluoride toxicity in humans. Fluoride metabolism and subsequently its body retention may be affected by physiological responses to acute exercise. This pilot study investigated the effect of exercise on plasma fluoride concentration, urinary fluoride excretion and fluoride renal clearance following no exercise and three exercise intensity conditions in nine healthy adults after taking a 1-mg Fluoride tablet. After no, light, moderate and vigorous exercise, respectively, the mean (SD) baseline-adjusted i) plasma fluoride concentration was 9.6(6.3), 11.4(6.3), 15.6(7.7) and 14.9(10.0)ng/ml; ii) rate of urinary fluoride excretion over 0-8h was 46(15), 44(22), 34(17) and 36(17)μg/h; and iii) rate of fluoride renal clearance was 26.5(9.0), 27.2(30.4), 13.1(20.4) and 18.3(34.9)ml/min. The observed trend of a rise in plasma fluoride concentration and decline in rate of fluoride renal clearance with increasing exercise intensity needs to be investigated in a larger trial. This study, which provides the first data on the effect of exercise with different intensities on fluoride metabolism in humans, informs sample size planning for any subsequent definitive trial, by providing a robust estimate of the variability of the effect.",

author = "Zohoori, {Fatemeh V.} and Alison Innerd and Azevedo, {Liane B.} and Whitford, {Gary M.} and Anne Maguire",

note = "Funding Information: The authors would like to thank Om Sah for laboratory analysis of samples as well as Georgios Tavoularis and Nicola Pace for their help in managing and running the exercise experiments. This study was supported by an internal grant from Teesside University. Publisher Copyright: {\textcopyright} 2015, Nature Publishing Group. All rights reserved.",

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AU - Maguire, Anne

N1 - Funding Information: The authors would like to thank Om Sah for laboratory analysis of samples as well as Georgios Tavoularis and Nicola Pace for their help in managing and running the exercise experiments. This study was supported by an internal grant from Teesside University. Publisher Copyright: © 2015, Nature Publishing Group. All rights reserved.

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N2 - An understanding of all aspects of fluoride metabolism is critical to identify its biological effects and avoid fluoride toxicity in humans. Fluoride metabolism and subsequently its body retention may be affected by physiological responses to acute exercise. This pilot study investigated the effect of exercise on plasma fluoride concentration, urinary fluoride excretion and fluoride renal clearance following no exercise and three exercise intensity conditions in nine healthy adults after taking a 1-mg Fluoride tablet. After no, light, moderate and vigorous exercise, respectively, the mean (SD) baseline-adjusted i) plasma fluoride concentration was 9.6(6.3), 11.4(6.3), 15.6(7.7) and 14.9(10.0)ng/ml; ii) rate of urinary fluoride excretion over 0-8h was 46(15), 44(22), 34(17) and 36(17)μg/h; and iii) rate of fluoride renal clearance was 26.5(9.0), 27.2(30.4), 13.1(20.4) and 18.3(34.9)ml/min. The observed trend of a rise in plasma fluoride concentration and decline in rate of fluoride renal clearance with increasing exercise intensity needs to be investigated in a larger trial. This study, which provides the first data on the effect of exercise with different intensities on fluoride metabolism in humans, informs sample size planning for any subsequent definitive trial, by providing a robust estimate of the variability of the effect.

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Effect of exercise on fluoride metabolism in adult humans: A pilot study

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