Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder

Nathan A. Kimbrel, Melanie E. Garrett, Michelle F. Dennis, Yutao Liu, Ilyas Patanam, Allison E. Ashley-Koch, Michael A. Hauser, Jean C. Beckham, John Mason, Marinell Miller-Mumford, Scott D. McDonald, Treven Pickett, Robin A. Hurley, Jared Rowland, Katherine H. Taber, Ruth E. Yoash-Gantz, Mira Brancu, Patrick S. Calhoun, Eric A. Dedert, Eric B. ElbogenJohn A. Fairbank, Kimberly T. Green, Jason D. Kilts, Angela C. Kirby, Christine E. Marx, Gregory McCarthy, Scott D. Moore, Rajendra A. Morey, Jennifer Naylor, Jennifer J. Runnals, Steven T. Szabo, Kristy A. Straits-Tröster, Larry A. Tupler, Elizabeth E. Van Voorhees, Ryan H. Wagner, Richard D. Weiner, Mid-Atlantic MIRECC Workgroup VA Mid-Atlantic MIRECC Workgroup

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The present study examined the association between genetic variation in the nicotinic receptor gene family (. CHRNA2, CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNA9, CHRNA10, CHRNB2, CHRNB3, CHRNB4) and the occurrence of posttraumatic stress disorder (PTSD). Clinical interviews were used to diagnose PTSD in 925 non-Hispanic Black (NHB) and 743 non-Hispanic White (NHW) participants. Trauma history and smoking status were assessed with self-report. No significant main effects or single nucleotide polymorphism (SNP) smoking interactions were observed among NHB participants; however, among NHW participants, a novel association between rs12898919 in the cholinergic receptor nicotinic alpha-5 (CHRNA5) gene and PTSD was observed. No other significant main effects or SNP * smoking interactions were identified among NHW participants. While preliminary, these findings provide continued support for the hypothesis that the CHRNA5 gene is associated with increased risk for PTSD. Limitations of the present study include cross-sectional design, relatively small sample sizes for genetic research, use of self-report to assess smoking status, and use of different methods to diagnose PTSD. Additional research in other samples of trauma-exposed participants is needed to identify the specific functional variant(s) responsible for the association observed between CHRNA5 and PTSD risk in the present study.

Original languageEnglish (US)
Pages (from-to)326-331
Number of pages6
JournalPsychiatry Research
Volume229
Issue number1-2
DOIs
StatePublished - Sep 30 2015

Fingerprint

Nicotinic Receptors
Post-Traumatic Stress Disorders
Cholinergic Receptors
Smoking
Genes
Self Report
Single Nucleotide Polymorphism
Genetic Research
Wounds and Injuries
Sample Size
Cross-Sectional Studies
Interviews
Research

Keywords

  • Gene
  • Genetic
  • Nicotine
  • PTSD
  • Posttraumatic stress disorder
  • Smoking
  • Trauma

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Kimbrel, N. A., Garrett, M. E., Dennis, M. F., Liu, Y., Patanam, I., Ashley-Koch, A. E., ... VA Mid-Atlantic MIRECC Workgroup, M-A. MIRECC. W. (2015). Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder. Psychiatry Research, 229(1-2), 326-331. https://doi.org/10.1016/j.psychres.2015.07.002

Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder. / Kimbrel, Nathan A.; Garrett, Melanie E.; Dennis, Michelle F.; Liu, Yutao; Patanam, Ilyas; Ashley-Koch, Allison E.; Hauser, Michael A.; Beckham, Jean C.; Mason, John; Miller-Mumford, Marinell; McDonald, Scott D.; Pickett, Treven; Hurley, Robin A.; Rowland, Jared; Taber, Katherine H.; Yoash-Gantz, Ruth E.; Brancu, Mira; Calhoun, Patrick S.; Dedert, Eric A.; Elbogen, Eric B.; Fairbank, John A.; Green, Kimberly T.; Kilts, Jason D.; Kirby, Angela C.; Marx, Christine E.; McCarthy, Gregory; Moore, Scott D.; Morey, Rajendra A.; Naylor, Jennifer; Runnals, Jennifer J.; Szabo, Steven T.; Straits-Tröster, Kristy A.; Tupler, Larry A.; Van Voorhees, Elizabeth E.; Wagner, Ryan H.; Weiner, Richard D.; VA Mid-Atlantic MIRECC Workgroup, Mid-Atlantic MIRECC Workgroup.

In: Psychiatry Research, Vol. 229, No. 1-2, 30.09.2015, p. 326-331.

Research output: Contribution to journalArticle

Kimbrel, NA, Garrett, ME, Dennis, MF, Liu, Y, Patanam, I, Ashley-Koch, AE, Hauser, MA, Beckham, JC, Mason, J, Miller-Mumford, M, McDonald, SD, Pickett, T, Hurley, RA, Rowland, J, Taber, KH, Yoash-Gantz, RE, Brancu, M, Calhoun, PS, Dedert, EA, Elbogen, EB, Fairbank, JA, Green, KT, Kilts, JD, Kirby, AC, Marx, CE, McCarthy, G, Moore, SD, Morey, RA, Naylor, J, Runnals, JJ, Szabo, ST, Straits-Tröster, KA, Tupler, LA, Van Voorhees, EE, Wagner, RH, Weiner, RD & VA Mid-Atlantic MIRECC Workgroup, M-AMIRECCW 2015, 'Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder', Psychiatry Research, vol. 229, no. 1-2, pp. 326-331. https://doi.org/10.1016/j.psychres.2015.07.002
Kimbrel, Nathan A. ; Garrett, Melanie E. ; Dennis, Michelle F. ; Liu, Yutao ; Patanam, Ilyas ; Ashley-Koch, Allison E. ; Hauser, Michael A. ; Beckham, Jean C. ; Mason, John ; Miller-Mumford, Marinell ; McDonald, Scott D. ; Pickett, Treven ; Hurley, Robin A. ; Rowland, Jared ; Taber, Katherine H. ; Yoash-Gantz, Ruth E. ; Brancu, Mira ; Calhoun, Patrick S. ; Dedert, Eric A. ; Elbogen, Eric B. ; Fairbank, John A. ; Green, Kimberly T. ; Kilts, Jason D. ; Kirby, Angela C. ; Marx, Christine E. ; McCarthy, Gregory ; Moore, Scott D. ; Morey, Rajendra A. ; Naylor, Jennifer ; Runnals, Jennifer J. ; Szabo, Steven T. ; Straits-Tröster, Kristy A. ; Tupler, Larry A. ; Van Voorhees, Elizabeth E. ; Wagner, Ryan H. ; Weiner, Richard D. ; VA Mid-Atlantic MIRECC Workgroup, Mid-Atlantic MIRECC Workgroup. / Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder. In: Psychiatry Research. 2015 ; Vol. 229, No. 1-2. pp. 326-331.
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AU - Ashley-Koch, Allison E.

AU - Hauser, Michael A.

AU - Beckham, Jean C.

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AU - Miller-Mumford, Marinell

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AU - Yoash-Gantz, Ruth E.

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AU - Calhoun, Patrick S.

AU - Dedert, Eric A.

AU - Elbogen, Eric B.

AU - Fairbank, John A.

AU - Green, Kimberly T.

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AU - Kirby, Angela C.

AU - Marx, Christine E.

AU - McCarthy, Gregory

AU - Moore, Scott D.

AU - Morey, Rajendra A.

AU - Naylor, Jennifer

AU - Runnals, Jennifer J.

AU - Szabo, Steven T.

AU - Straits-Tröster, Kristy A.

AU - Tupler, Larry A.

AU - Van Voorhees, Elizabeth E.

AU - Wagner, Ryan H.

AU - Weiner, Richard D.

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