Effect of gonadotropin-releasing hormone hypogonadism on insulin action as assessed by hyperglycemic clamp studies in men

Subodhsingh Chauhan; Karen Collins; Michael Kruger; Michael P. Diamond

doi:10.1016/j.fertnstert.2003.08.052

Effect of gonadotropin-releasing hormone hypogonadism on insulin action as assessed by hyperglycemic clamp studies in men

Subodhsingh Chauhan, Karen Collins, Michael Kruger, Michael P. Diamond

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Objective To investigate the effects of decreasing androgen levels on insulin action, in view of the relationship between hyperandrogenism and impaired insulin action in women with polycystic ovary syndrome. Design Prospective, clinical study. Setting University hospital. Patient(s) Ten normal healthy men. Intervention(s) Gonadotropin-releasing hormone (GnRH) agonist, 3. 75 mg, administered monthly for 3 months. Main outcome measure(s) Insulin action (M/I ratio). Result(s) The M/I ratio decreased from 0.24 ± 0.04 to 0.17 ± 0.04 after GnRH agonist therapy. Conclusion(s) In normal men, administration of a GnRH analogue was associated with a decrease in both testosterone levels and insulin action.

Original language	English (US)
Pages (from-to)	1092-1098
Number of pages	7
Journal	Fertility and sterility
Volume	81
Issue number	4
DOIs	https://doi.org/10.1016/j.fertnstert.2003.08.052
State	Published - Apr 2004
Externally published	Yes

Keywords

GnRH
Hyperglycemic clamp
Insulin action
M/I ratio
Testosterone

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

Access to Document

10.1016/j.fertnstert.2003.08.052

Cite this

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title = "Effect of gonadotropin-releasing hormone hypogonadism on insulin action as assessed by hyperglycemic clamp studies in men",

abstract = "Objective To investigate the effects of decreasing androgen levels on insulin action, in view of the relationship between hyperandrogenism and impaired insulin action in women with polycystic ovary syndrome. Design Prospective, clinical study. Setting University hospital. Patient(s) Ten normal healthy men. Intervention(s) Gonadotropin-releasing hormone (GnRH) agonist, 3. 75 mg, administered monthly for 3 months. Main outcome measure(s) Insulin action (M/I ratio). Result(s) The M/I ratio decreased from 0.24 ± 0.04 to 0.17 ± 0.04 after GnRH agonist therapy. Conclusion(s) In normal men, administration of a GnRH analogue was associated with a decrease in both testosterone levels and insulin action.",

keywords = "GnRH, Hyperglycemic clamp, Insulin action, M/I ratio, Testosterone",

author = "Subodhsingh Chauhan and Karen Collins and Michael Kruger and Diamond, {Michael P.}",

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AU - Chauhan, Subodhsingh

AU - Collins, Karen

AU - Kruger, Michael

AU - Diamond, Michael P.

PY - 2004/4

Y1 - 2004/4

N2 - Objective To investigate the effects of decreasing androgen levels on insulin action, in view of the relationship between hyperandrogenism and impaired insulin action in women with polycystic ovary syndrome. Design Prospective, clinical study. Setting University hospital. Patient(s) Ten normal healthy men. Intervention(s) Gonadotropin-releasing hormone (GnRH) agonist, 3. 75 mg, administered monthly for 3 months. Main outcome measure(s) Insulin action (M/I ratio). Result(s) The M/I ratio decreased from 0.24 ± 0.04 to 0.17 ± 0.04 after GnRH agonist therapy. Conclusion(s) In normal men, administration of a GnRH analogue was associated with a decrease in both testosterone levels and insulin action.

AB - Objective To investigate the effects of decreasing androgen levels on insulin action, in view of the relationship between hyperandrogenism and impaired insulin action in women with polycystic ovary syndrome. Design Prospective, clinical study. Setting University hospital. Patient(s) Ten normal healthy men. Intervention(s) Gonadotropin-releasing hormone (GnRH) agonist, 3. 75 mg, administered monthly for 3 months. Main outcome measure(s) Insulin action (M/I ratio). Result(s) The M/I ratio decreased from 0.24 ± 0.04 to 0.17 ± 0.04 after GnRH agonist therapy. Conclusion(s) In normal men, administration of a GnRH analogue was associated with a decrease in both testosterone levels and insulin action.

KW - GnRH

KW - Hyperglycemic clamp

KW - Insulin action

KW - M/I ratio

KW - Testosterone

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Effect of gonadotropin-releasing hormone hypogonadism on insulin action as assessed by hyperglycemic clamp studies in men

Abstract

Keywords

ASJC Scopus subject areas

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