Effect of gonadotropin-releasing hormone hypogonadism on insulin action as assessed by hyperglycemic clamp studies in men

Subodhsingh Chauhan, Karen Collins, Michael Kruger, Michael Peter Diamond

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Objective To investigate the effects of decreasing androgen levels on insulin action, in view of the relationship between hyperandrogenism and impaired insulin action in women with polycystic ovary syndrome. Design Prospective, clinical study. Setting University hospital. Patient(s) Ten normal healthy men. Intervention(s) Gonadotropin-releasing hormone (GnRH) agonist, 3. 75 mg, administered monthly for 3 months. Main outcome measure(s) Insulin action (M/I ratio). Result(s) The M/I ratio decreased from 0.24 ± 0.04 to 0.17 ± 0.04 after GnRH agonist therapy. Conclusion(s) In normal men, administration of a GnRH analogue was associated with a decrease in both testosterone levels and insulin action.

Original languageEnglish (US)
Pages (from-to)1092-1098
Number of pages7
JournalFertility and Sterility
Volume81
Issue number4
DOIs
StatePublished - Apr 1 2004
Externally publishedYes

Keywords

  • GnRH
  • Hyperglycemic clamp
  • Insulin action
  • M/I ratio
  • Testosterone

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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