Effect of gonadotropin-releasing-hormone-induced hypogonadism on insulin action as assessed by euglycemic clamp studies in men

Subodhsingh Chauhan, Michael P. Diamond

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objective: In view of the relationship between hyperandrogenism and impaired insulin action in women with polycystic ovarian syndrome, we sought to investigate the effects of decreasing androgen levels on insulin action in men. Design: Prospective clinical study. Setting: University hospital. Patient(s): Ten normal healthy men. Intervention(s): GnRH agonist, 3.75 mg monthly for 3 months. Main Outcome Measure(s): Rate of glucose uptake, serum insulin, and glucose levels. Result(s): GnRH treatment caused a significant fall in circulating testosterone levels, from 572 ± 58 ng/dL to 178 ± 66 ng/dL (P<.05). However, as assessed by euglycemic hyperinsulinemic clamp studies, there was no significant change in glucose uptake. Conclusion(s): In normal men, administration of a GnRH analogue was associated with a decrease in testosterone levels but not in insulin action.

Original languageEnglish (US)
Pages (from-to)186-190
Number of pages5
JournalFertility and sterility
Volume84
Issue number1
DOIs
StatePublished - Jul 1 2005
Externally publishedYes

Keywords

  • Euglycemic clamp
  • GnRH
  • Insulin action
  • Testosterone

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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