Effect of gonadotropin-releasing-hormone-induced hypogonadism on insulin action as assessed by euglycemic clamp studies in men

Subodhsingh Chauhan, Michael Peter Diamond

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: In view of the relationship between hyperandrogenism and impaired insulin action in women with polycystic ovarian syndrome, we sought to investigate the effects of decreasing androgen levels on insulin action in men. Design: Prospective clinical study. Setting: University hospital. Patient(s): Ten normal healthy men. Intervention(s): GnRH agonist, 3.75 mg monthly for 3 months. Main Outcome Measure(s): Rate of glucose uptake, serum insulin, and glucose levels. Result(s): GnRH treatment caused a significant fall in circulating testosterone levels, from 572 ± 58 ng/dL to 178 ± 66 ng/dL (P<.05). However, as assessed by euglycemic hyperinsulinemic clamp studies, there was no significant change in glucose uptake. Conclusion(s): In normal men, administration of a GnRH analogue was associated with a decrease in testosterone levels but not in insulin action.

Original languageEnglish (US)
Pages (from-to)186-190
Number of pages5
JournalFertility and Sterility
Volume84
Issue number1
DOIs
StatePublished - Jul 1 2005
Externally publishedYes

Fingerprint

Glucose Clamp Technique
Hypogonadism
Gonadotropin-Releasing Hormone
Insulin
Glucose
Testosterone
Hyperandrogenism
Polycystic Ovary Syndrome
Androgens
Outcome Assessment (Health Care)
Prospective Studies
Serum
Therapeutics

Keywords

  • Euglycemic clamp
  • GnRH
  • Insulin action
  • Testosterone

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Effect of gonadotropin-releasing-hormone-induced hypogonadism on insulin action as assessed by euglycemic clamp studies in men. / Chauhan, Subodhsingh; Diamond, Michael Peter.

In: Fertility and Sterility, Vol. 84, No. 1, 01.07.2005, p. 186-190.

Research output: Contribution to journalArticle

@article{1a05b5a211184c5a97811afccad60432,
title = "Effect of gonadotropin-releasing-hormone-induced hypogonadism on insulin action as assessed by euglycemic clamp studies in men",
abstract = "Objective: In view of the relationship between hyperandrogenism and impaired insulin action in women with polycystic ovarian syndrome, we sought to investigate the effects of decreasing androgen levels on insulin action in men. Design: Prospective clinical study. Setting: University hospital. Patient(s): Ten normal healthy men. Intervention(s): GnRH agonist, 3.75 mg monthly for 3 months. Main Outcome Measure(s): Rate of glucose uptake, serum insulin, and glucose levels. Result(s): GnRH treatment caused a significant fall in circulating testosterone levels, from 572 ± 58 ng/dL to 178 ± 66 ng/dL (P<.05). However, as assessed by euglycemic hyperinsulinemic clamp studies, there was no significant change in glucose uptake. Conclusion(s): In normal men, administration of a GnRH analogue was associated with a decrease in testosterone levels but not in insulin action.",
keywords = "Euglycemic clamp, GnRH, Insulin action, Testosterone",
author = "Subodhsingh Chauhan and Diamond, {Michael Peter}",
year = "2005",
month = "7",
day = "1",
doi = "10.1016/j.fertnstert.2005.01.101",
language = "English (US)",
volume = "84",
pages = "186--190",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Effect of gonadotropin-releasing-hormone-induced hypogonadism on insulin action as assessed by euglycemic clamp studies in men

AU - Chauhan, Subodhsingh

AU - Diamond, Michael Peter

PY - 2005/7/1

Y1 - 2005/7/1

N2 - Objective: In view of the relationship between hyperandrogenism and impaired insulin action in women with polycystic ovarian syndrome, we sought to investigate the effects of decreasing androgen levels on insulin action in men. Design: Prospective clinical study. Setting: University hospital. Patient(s): Ten normal healthy men. Intervention(s): GnRH agonist, 3.75 mg monthly for 3 months. Main Outcome Measure(s): Rate of glucose uptake, serum insulin, and glucose levels. Result(s): GnRH treatment caused a significant fall in circulating testosterone levels, from 572 ± 58 ng/dL to 178 ± 66 ng/dL (P<.05). However, as assessed by euglycemic hyperinsulinemic clamp studies, there was no significant change in glucose uptake. Conclusion(s): In normal men, administration of a GnRH analogue was associated with a decrease in testosterone levels but not in insulin action.

AB - Objective: In view of the relationship between hyperandrogenism and impaired insulin action in women with polycystic ovarian syndrome, we sought to investigate the effects of decreasing androgen levels on insulin action in men. Design: Prospective clinical study. Setting: University hospital. Patient(s): Ten normal healthy men. Intervention(s): GnRH agonist, 3.75 mg monthly for 3 months. Main Outcome Measure(s): Rate of glucose uptake, serum insulin, and glucose levels. Result(s): GnRH treatment caused a significant fall in circulating testosterone levels, from 572 ± 58 ng/dL to 178 ± 66 ng/dL (P<.05). However, as assessed by euglycemic hyperinsulinemic clamp studies, there was no significant change in glucose uptake. Conclusion(s): In normal men, administration of a GnRH analogue was associated with a decrease in testosterone levels but not in insulin action.

KW - Euglycemic clamp

KW - GnRH

KW - Insulin action

KW - Testosterone

UR - http://www.scopus.com/inward/record.url?scp=22244439587&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22244439587&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2005.01.101

DO - 10.1016/j.fertnstert.2005.01.101

M3 - Article

VL - 84

SP - 186

EP - 190

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 1

ER -