Effect of high K+ exposure on phosphoinositide turnover of frog skeletal muscle in the absence of external calcium and in the presence of dantrolene sodium

J. H. Sun, Zheng Dong, K. Y. Chen, P. H. Zhu

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Abstract

To explore the role of the depolarization in high K+ induced enhancement of phosphoinositide turnover in frog skeletal muscle, the effect of Ca2+ free high K+ solution saturated with dantrolene sodium (DaNa) was investigated. It was found that, in comparison with the effect of normal high K+ solution (Dong et al. 1992), the turnover of phosphoinositides was similarly enhanced, and the contracture significantly reduced, though not completely prevented. It was indicated that the depolarization was still accompanied by a rise of myoplasmic free calcium. In view of the calcium dependence of phospholipase C activity, the present study supports the notion that elevation of [Ca2+](i) is not the only factor and depolarization probably plays some roles in the high K+ induced enhancement of phosphoinositide turnover.

Original languageEnglish (US)
Pages (from-to)64-70
Number of pages7
JournalChinese Journal of Physiological Sciences
Volume13
Issue number1
Publication statusPublished - Jan 1 1997
Externally publishedYes

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Keywords

  • Dantrolene sodium
  • High potassium
  • Phosphoinositide
  • Skeletal muscle

ASJC Scopus subject areas

  • Physiology

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