Effect of History of Mild Traumatic Brain Injury on Optic Nerve Sheath Diameter Changes after Valsalva Maneuver

Matthew L Lyon, Parth Agrawal, Kyle Friez, Richard D. Gordon, Ivan Morales, Li Fang Zhang, Hongyan Xu, Ian M. Heger, Robert W Gibson

Research output: Contribution to journalArticle

Abstract

Optic nerve sheath diameter (ONSD) measured by transocular ultrasound is a marker of real-time intracranial pressure (ICP). The objective of this study was to evaluate the association between optic nerve sheath (ONS) dilation after a Valsalva maneuver and a prior history of mild to moderate traumatic brain injury (mTBI) in a heterogeneous sample of participants. Participants were excluded if they had had a recent brain injury, were symptomatic from a prior brain injury, had a history consistent with severe TBI and/or had undergone intracranial surgery. Ninety-five participants with and without a history of mTBI were included in the study. Transocular ultrasound of the ONS was performed before and after a Valsalva maneuver. Differences in the ONSD before and after a Valsalva maneuver were analyzed and correlated to the participants' history of mTBI. Baseline ONSD measurements between groups were not statistically significant. Following Valsalva, participants with a history of mTBI had a statistically significant increase in the ONSD compared with participants with no history of mTBI. This significant difference persisted after controlling for age, race, and sex. This study demonstrated an association between a prior history of mTBI and dilation of the ONS after Valsalva maneuver in a sample of asymptomatic participants, which was not seen in participants without a history of mTBI.

Original languageEnglish (US)
Pages (from-to)695-702
Number of pages8
JournalJournal of Neurotrauma
Volume35
Issue number4
DOIs
StatePublished - Feb 15 2018

Fingerprint

Brain Concussion
Valsalva Maneuver
Optic Nerve
Brain Injuries
Dilatation
Intracranial Pressure
Traumatic Brain Injury
History

Keywords

  • ICP
  • ONS
  • Remote brain injury
  • TBI
  • Ultrasound

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Effect of History of Mild Traumatic Brain Injury on Optic Nerve Sheath Diameter Changes after Valsalva Maneuver. / Lyon, Matthew L; Agrawal, Parth; Friez, Kyle; Gordon, Richard D.; Morales, Ivan; Fang Zhang, Li; Xu, Hongyan; Heger, Ian M.; Gibson, Robert W.

In: Journal of Neurotrauma, Vol. 35, No. 4, 15.02.2018, p. 695-702.

Research output: Contribution to journalArticle

Lyon, Matthew L ; Agrawal, Parth ; Friez, Kyle ; Gordon, Richard D. ; Morales, Ivan ; Fang Zhang, Li ; Xu, Hongyan ; Heger, Ian M. ; Gibson, Robert W. / Effect of History of Mild Traumatic Brain Injury on Optic Nerve Sheath Diameter Changes after Valsalva Maneuver. In: Journal of Neurotrauma. 2018 ; Vol. 35, No. 4. pp. 695-702.
@article{5f7deb4d908148faa7a3f1daf5686654,
title = "Effect of History of Mild Traumatic Brain Injury on Optic Nerve Sheath Diameter Changes after Valsalva Maneuver",
abstract = "Optic nerve sheath diameter (ONSD) measured by transocular ultrasound is a marker of real-time intracranial pressure (ICP). The objective of this study was to evaluate the association between optic nerve sheath (ONS) dilation after a Valsalva maneuver and a prior history of mild to moderate traumatic brain injury (mTBI) in a heterogeneous sample of participants. Participants were excluded if they had had a recent brain injury, were symptomatic from a prior brain injury, had a history consistent with severe TBI and/or had undergone intracranial surgery. Ninety-five participants with and without a history of mTBI were included in the study. Transocular ultrasound of the ONS was performed before and after a Valsalva maneuver. Differences in the ONSD before and after a Valsalva maneuver were analyzed and correlated to the participants' history of mTBI. Baseline ONSD measurements between groups were not statistically significant. Following Valsalva, participants with a history of mTBI had a statistically significant increase in the ONSD compared with participants with no history of mTBI. This significant difference persisted after controlling for age, race, and sex. This study demonstrated an association between a prior history of mTBI and dilation of the ONS after Valsalva maneuver in a sample of asymptomatic participants, which was not seen in participants without a history of mTBI.",
keywords = "ICP, ONS, Remote brain injury, TBI, Ultrasound",
author = "Lyon, {Matthew L} and Parth Agrawal and Kyle Friez and Gordon, {Richard D.} and Ivan Morales and {Fang Zhang}, Li and Hongyan Xu and Heger, {Ian M.} and Gibson, {Robert W}",
year = "2018",
month = "2",
day = "15",
doi = "10.1089/neu.2017.5164",
language = "English (US)",
volume = "35",
pages = "695--702",
journal = "Journal of Neurotrauma",
issn = "0897-7151",
publisher = "Mary Ann Liebert Inc.",
number = "4",

}

TY - JOUR

T1 - Effect of History of Mild Traumatic Brain Injury on Optic Nerve Sheath Diameter Changes after Valsalva Maneuver

AU - Lyon, Matthew L

AU - Agrawal, Parth

AU - Friez, Kyle

AU - Gordon, Richard D.

AU - Morales, Ivan

AU - Fang Zhang, Li

AU - Xu, Hongyan

AU - Heger, Ian M.

AU - Gibson, Robert W

PY - 2018/2/15

Y1 - 2018/2/15

N2 - Optic nerve sheath diameter (ONSD) measured by transocular ultrasound is a marker of real-time intracranial pressure (ICP). The objective of this study was to evaluate the association between optic nerve sheath (ONS) dilation after a Valsalva maneuver and a prior history of mild to moderate traumatic brain injury (mTBI) in a heterogeneous sample of participants. Participants were excluded if they had had a recent brain injury, were symptomatic from a prior brain injury, had a history consistent with severe TBI and/or had undergone intracranial surgery. Ninety-five participants with and without a history of mTBI were included in the study. Transocular ultrasound of the ONS was performed before and after a Valsalva maneuver. Differences in the ONSD before and after a Valsalva maneuver were analyzed and correlated to the participants' history of mTBI. Baseline ONSD measurements between groups were not statistically significant. Following Valsalva, participants with a history of mTBI had a statistically significant increase in the ONSD compared with participants with no history of mTBI. This significant difference persisted after controlling for age, race, and sex. This study demonstrated an association between a prior history of mTBI and dilation of the ONS after Valsalva maneuver in a sample of asymptomatic participants, which was not seen in participants without a history of mTBI.

AB - Optic nerve sheath diameter (ONSD) measured by transocular ultrasound is a marker of real-time intracranial pressure (ICP). The objective of this study was to evaluate the association between optic nerve sheath (ONS) dilation after a Valsalva maneuver and a prior history of mild to moderate traumatic brain injury (mTBI) in a heterogeneous sample of participants. Participants were excluded if they had had a recent brain injury, were symptomatic from a prior brain injury, had a history consistent with severe TBI and/or had undergone intracranial surgery. Ninety-five participants with and without a history of mTBI were included in the study. Transocular ultrasound of the ONS was performed before and after a Valsalva maneuver. Differences in the ONSD before and after a Valsalva maneuver were analyzed and correlated to the participants' history of mTBI. Baseline ONSD measurements between groups were not statistically significant. Following Valsalva, participants with a history of mTBI had a statistically significant increase in the ONSD compared with participants with no history of mTBI. This significant difference persisted after controlling for age, race, and sex. This study demonstrated an association between a prior history of mTBI and dilation of the ONS after Valsalva maneuver in a sample of asymptomatic participants, which was not seen in participants without a history of mTBI.

KW - ICP

KW - ONS

KW - Remote brain injury

KW - TBI

KW - Ultrasound

UR - http://www.scopus.com/inward/record.url?scp=85041713124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041713124&partnerID=8YFLogxK

U2 - 10.1089/neu.2017.5164

DO - 10.1089/neu.2017.5164

M3 - Article

VL - 35

SP - 695

EP - 702

JO - Journal of Neurotrauma

JF - Journal of Neurotrauma

SN - 0897-7151

IS - 4

ER -