Effect of hypertension and hypertrophy on coronary microvascular pressure

M. Fujii, D. W. Nuno, K. G. Lamping, K. C. Dellsperger, C. L. Eastham, D. G. Harrison

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We tested the hypothesis that transmural differences in coronary microvascular pressures may be greater in the setting of hypertension and left ventricular hypertrophy. Epicardial and endocardial microvascular pressures were measured in isolated lidocaine-arrested hearts during adenosine vasodilation. In both normotensive (n = 19) and hypertensive (one clip, one kidney, n = 10) dogs, microvascular pressures in endocardial arterioles at 60, 70, 80, 90, and 100 mm Hg of left main coronary perfusion pressures were lower than in epicardial arterioles (p < 0.05 at all perfusion pressures). The pressures in epicardial arterioles as a percentage of the left main coronary perfusion pressure were similar in normotensive versus hypertensive hearts at all perfusion pressures. In contrast, the pressures in endocardium at 90 and 100 mm Hg of perfusion pressure were significantly (p < 0.05) lower in dogs with hypertension and hypertrophy than in the controls (41 ± 4 versus 50 ± 2 and 40 ± 4 versus 50 ± 3 mm Hg at 90 and 100 mm Hg of perfusion pressure, respectively). Thus, there is a greater transmural resistance to microvascular perfusion in hearts with myocardial hypertrophy secondary to hypertension. This is likely due to differences in the vascular anatomy, secondary to hypertension and hypertrophy, and may contribute to vulnerabilities in subendocardial ischemia encountered in this condition.

Original languageEnglish (US)
Pages (from-to)120-126
Number of pages7
JournalCirculation Research
Volume71
Issue number1
DOIs
StatePublished - Jan 1 1992

Fingerprint

Hypertrophy
Hypertension
Pressure
Perfusion
Arterioles
Dogs
Endocardium
Left Ventricular Hypertrophy
Lidocaine
Surgical Instruments
Vasodilation
Adenosine
Blood Vessels
Anatomy
Ischemia
Kidney

Keywords

  • microcirculation
  • microvascular pressure
  • renal hypertension

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Fujii, M., Nuno, D. W., Lamping, K. G., Dellsperger, K. C., Eastham, C. L., & Harrison, D. G. (1992). Effect of hypertension and hypertrophy on coronary microvascular pressure. Circulation Research, 71(1), 120-126. https://doi.org/10.1161/01.RES.71.1.120

Effect of hypertension and hypertrophy on coronary microvascular pressure. / Fujii, M.; Nuno, D. W.; Lamping, K. G.; Dellsperger, K. C.; Eastham, C. L.; Harrison, D. G.

In: Circulation Research, Vol. 71, No. 1, 01.01.1992, p. 120-126.

Research output: Contribution to journalArticle

Fujii, M, Nuno, DW, Lamping, KG, Dellsperger, KC, Eastham, CL & Harrison, DG 1992, 'Effect of hypertension and hypertrophy on coronary microvascular pressure', Circulation Research, vol. 71, no. 1, pp. 120-126. https://doi.org/10.1161/01.RES.71.1.120
Fujii M, Nuno DW, Lamping KG, Dellsperger KC, Eastham CL, Harrison DG. Effect of hypertension and hypertrophy on coronary microvascular pressure. Circulation Research. 1992 Jan 1;71(1):120-126. https://doi.org/10.1161/01.RES.71.1.120
Fujii, M. ; Nuno, D. W. ; Lamping, K. G. ; Dellsperger, K. C. ; Eastham, C. L. ; Harrison, D. G. / Effect of hypertension and hypertrophy on coronary microvascular pressure. In: Circulation Research. 1992 ; Vol. 71, No. 1. pp. 120-126.
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