Effect of hypoxia on release of vasoactive substances from cultured pulmonary arterial and aortic endothelial cells

Yunchao Su, Wang Di-xun

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effect of hypoxia on the production and release of vasoactive substances from endothelial cells of pulmonary artery (PAECs) and aorta (AECs) was studied. The results indicated that the overall effect of tne long half-life vasoactive substances released from PAECs and AECs was vasoconstrictive. The long half-life lipid-soluble substances produced by PAECs and AECs were vasodilative, and did not change in hypoxia. However, the long half-life water-soluble heat-unstable and heat-stable ones were vasoconstrictive. Hypoxia could reduce the release of the former and promote that of the latter which might be peptides. The PAECs could release specific long half-life mediator which was pulmonary artery-constrictive, water-soluble, heat-unstable, and not related to hypoxia. Hypoxia inhibited the production of PGI2, a short half-life vasodilator, in PAECs, but not in AECs.

Original languageEnglish (US)
Pages (from-to)88-92
Number of pages5
JournalJournal of Tongji Medical University
Volume13
Issue number2
DOIs
StatePublished - Jun 1 1993
Externally publishedYes

Fingerprint

Endothelial cells
Half-Life
Endothelial Cells
Aorta
Lung
Hot Temperature
Water
Pulmonary Artery
Epoprostenol
Vasodilator Agents
Lipids
Peptides
Hypoxia
Half-life

Keywords

  • endofhelium-derived constricting factor (EDCF)
  • endothelium
  • hypoxia
  • prostaglandins

ASJC Scopus subject areas

  • Management of Technology and Innovation

Cite this

Effect of hypoxia on release of vasoactive substances from cultured pulmonary arterial and aortic endothelial cells. / Su, Yunchao; Di-xun, Wang.

In: Journal of Tongji Medical University, Vol. 13, No. 2, 01.06.1993, p. 88-92.

Research output: Contribution to journalArticle

@article{a951588b17234d05b78e59fa59083aa2,
title = "Effect of hypoxia on release of vasoactive substances from cultured pulmonary arterial and aortic endothelial cells",
abstract = "The effect of hypoxia on the production and release of vasoactive substances from endothelial cells of pulmonary artery (PAECs) and aorta (AECs) was studied. The results indicated that the overall effect of tne long half-life vasoactive substances released from PAECs and AECs was vasoconstrictive. The long half-life lipid-soluble substances produced by PAECs and AECs were vasodilative, and did not change in hypoxia. However, the long half-life water-soluble heat-unstable and heat-stable ones were vasoconstrictive. Hypoxia could reduce the release of the former and promote that of the latter which might be peptides. The PAECs could release specific long half-life mediator which was pulmonary artery-constrictive, water-soluble, heat-unstable, and not related to hypoxia. Hypoxia inhibited the production of PGI2, a short half-life vasodilator, in PAECs, but not in AECs.",
keywords = "endofhelium-derived constricting factor (EDCF), endothelium, hypoxia, prostaglandins",
author = "Yunchao Su and Wang Di-xun",
year = "1993",
month = "6",
day = "1",
doi = "10.1007/BF02887922",
language = "English (US)",
volume = "13",
pages = "88--92",
journal = "Current Medical Science",
issn = "2096-5230",
publisher = "Huazhong University of Science and Technology",
number = "2",

}

TY - JOUR

T1 - Effect of hypoxia on release of vasoactive substances from cultured pulmonary arterial and aortic endothelial cells

AU - Su, Yunchao

AU - Di-xun, Wang

PY - 1993/6/1

Y1 - 1993/6/1

N2 - The effect of hypoxia on the production and release of vasoactive substances from endothelial cells of pulmonary artery (PAECs) and aorta (AECs) was studied. The results indicated that the overall effect of tne long half-life vasoactive substances released from PAECs and AECs was vasoconstrictive. The long half-life lipid-soluble substances produced by PAECs and AECs were vasodilative, and did not change in hypoxia. However, the long half-life water-soluble heat-unstable and heat-stable ones were vasoconstrictive. Hypoxia could reduce the release of the former and promote that of the latter which might be peptides. The PAECs could release specific long half-life mediator which was pulmonary artery-constrictive, water-soluble, heat-unstable, and not related to hypoxia. Hypoxia inhibited the production of PGI2, a short half-life vasodilator, in PAECs, but not in AECs.

AB - The effect of hypoxia on the production and release of vasoactive substances from endothelial cells of pulmonary artery (PAECs) and aorta (AECs) was studied. The results indicated that the overall effect of tne long half-life vasoactive substances released from PAECs and AECs was vasoconstrictive. The long half-life lipid-soluble substances produced by PAECs and AECs were vasodilative, and did not change in hypoxia. However, the long half-life water-soluble heat-unstable and heat-stable ones were vasoconstrictive. Hypoxia could reduce the release of the former and promote that of the latter which might be peptides. The PAECs could release specific long half-life mediator which was pulmonary artery-constrictive, water-soluble, heat-unstable, and not related to hypoxia. Hypoxia inhibited the production of PGI2, a short half-life vasodilator, in PAECs, but not in AECs.

KW - endofhelium-derived constricting factor (EDCF)

KW - endothelium

KW - hypoxia

KW - prostaglandins

UR - http://www.scopus.com/inward/record.url?scp=0027356803&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027356803&partnerID=8YFLogxK

U2 - 10.1007/BF02887922

DO - 10.1007/BF02887922

M3 - Article

VL - 13

SP - 88

EP - 92

JO - Current Medical Science

JF - Current Medical Science

SN - 2096-5230

IS - 2

ER -