Effect of ibuprofen use on muscle soreness, damage, and performance: A preliminary investigation

Scott Hasson, Jerry C. Daniels, Jon G. Divine, Bruce R. Niebuhr, Shirley Richmond, Philip G. Stein, Jay H. Williams

Research output: Contribution to journalArticle

112 Scopus citations

Abstract

Twenty subjects were randomly assigned to: 1) prophylactic ibuprofen (N = 5) [400 mg TID initiated 4 h before collection of baseline data and strenuous eccentric exercise bout], 2) therapeutic ibuprofen (N = 5) [400 mg TID initiated 24 h after baseline], 3) placebo (N = 5), or 4) control (N = 5). Muscle soreness perception, plasma creatine kinase, knee extensor torque, and EMG of the quadriceps were evaluated at baseline, 24, and 48 h. The prophylactic ibuprofen group had between 40 and 50% less muscle soreness perception and significantly less decline in isometric, concentric, and eccentric torque at 24 h compared with the other three groups (P < 0.05). At 48 h both prophylactic and therapeutic ibuprofen had significantly less muscle soreness perception and decline in torque than the placebo and control groups (P< 0.05). There was no difference between the amount of muscle damage between the four groups at 24 and 48 h. Vastus medialis and lateralis EMG magnitude decreased across time. Vastus lateralis EMG magnitude had significantly less decline from baseline for prophylactic ibuprofen compared with the other three treatments at 24 h, while both prophylactic and therapeutic ibuprofen had significantly less decline at 48 h. These data indicate that a prophylactic dosage of ibuprofen does not prevent CK release from muscle, but does decrease muscle soreness perception and may assist in restoring muscle function.

Original languageEnglish (US)
Pages (from-to)9-17
Number of pages9
JournalMedicine and Science in Sports and Exercise
Volume25
Issue number1
DOIs
StatePublished - Jan 1 1993

Keywords

  • Creatine kinase
  • Delayed onset muscle soreness
  • Eccentric contractions
  • Nonsteroidal anti-inflammatory

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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    Hasson, S., Daniels, J. C., Divine, J. G., Niebuhr, B. R., Richmond, S., Stein, P. G., & Williams, J. H. (1993). Effect of ibuprofen use on muscle soreness, damage, and performance: A preliminary investigation. Medicine and Science in Sports and Exercise, 25(1), 9-17. https://doi.org/10.1249/00005768-199301000-00003