Effect of interleukin-2 and mitogen on in vitro immunoglobulin production by peripheral blood lymphocytes from patients with selective IgM deficiency

J. E. Moffitt, Margaret Frank Guill, Betty Beasley Wray, D. A. Brown, N. W. Peacocke, E. W. Ades

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Immunoglobulin production by mitogen and recombinant interleukin-2-(rIL-2)-stimulated lymphocytes from IgM-deficient patients was studied. The findings were that subnormal serum IgM levels did not necessarily predict defective in vitro IgG or IgM production, lymphocytes from some IgM-deficient patients exhibited defective T cell function, and rIL-2 did not enhance defective in vitro immunoglobulin production.

Original languageEnglish (US)
Pages (from-to)424-427
Number of pages4
JournalAnnals of Allergy
Volume61
Issue number6
StatePublished - Dec 1 1988

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Mitogens
Interleukin-2
Immunoglobulin M
Immunoglobulins
Lymphocytes
Immunoglobulin G
T-Lymphocytes
In Vitro Techniques
Serum

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Effect of interleukin-2 and mitogen on in vitro immunoglobulin production by peripheral blood lymphocytes from patients with selective IgM deficiency. / Moffitt, J. E.; Guill, Margaret Frank; Wray, Betty Beasley; Brown, D. A.; Peacocke, N. W.; Ades, E. W.

In: Annals of Allergy, Vol. 61, No. 6, 01.12.1988, p. 424-427.

Research output: Contribution to journalArticle

Moffitt, J. E. ; Guill, Margaret Frank ; Wray, Betty Beasley ; Brown, D. A. ; Peacocke, N. W. ; Ades, E. W. / Effect of interleukin-2 and mitogen on in vitro immunoglobulin production by peripheral blood lymphocytes from patients with selective IgM deficiency. In: Annals of Allergy. 1988 ; Vol. 61, No. 6. pp. 424-427.
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