Effect of metformin on periimplant wound healing in a rat model of type 2 diabetes

Kimberly Ann S. Inouye, Frederick C. Bisch, Mohammed Elsayed Elsalanty, Ibrahim Zakhary, Rania M. Khashaba, James L. Borke

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

PURPOSE:: To investigate the effects of hyperglycemia and metformin (a popular biguanide antidiabetic) on periimplant healing. METHODS:: Thirty-six male rats were assigned to 3 groups: (1) nondiabetic Wistar-Kyoto rats (controls), (2) Goto-Kakizaki (GK) spontaneously diabetic rats (GK group), and (3) GK rats were fed metformin (100 mg/kg body weight per day) in their water for 4 weeks (GK + Met group). The right maxillary first molars were extracted and sites were allowed 1 month to heal. Titanium implants (1 × 3 mm) were placed in healed extraction sites. Six rats from each group were analyzed at weeks 1 and 4 by micro computed tomography for bone/implant contact ratio, percent bone volume, trabecular number, and bone mineral density. Blood was also analyzed for glucose, HbA1c, and pyridinoline (PYD). RESULTS:: At week 1, glucose levels in the GK-Met rats were high, and all bone parameters were similar to GK rats (lower bone parameters and higher PYD than controls). At week 4, glucose levels in the GK-Met rats and all parameters were similar to controls. CONCLUSIONS:: Hyperglycemic GK type 2 diabetic rats showed improved blood glucose and wound healing around oral implants after metformin administration.

Original languageEnglish (US)
Pages (from-to)319-327
Number of pages9
JournalImplant Dentistry
Volume23
Issue number3
DOIs
StatePublished - Jan 1 2014

Fingerprint

Metformin
Wound Healing
Type 2 Diabetes Mellitus
Bone and Bones
Glucose
Biguanides
Inbred WKY Rats
Titanium
Hypoglycemic Agents
Hyperglycemia
Bone Density
Blood Glucose
Tomography
Body Weight
Water

Keywords

  • Dental implants
  • Metformin
  • Rat model
  • Type 2 diabetes

ASJC Scopus subject areas

  • Oral Surgery

Cite this

Effect of metformin on periimplant wound healing in a rat model of type 2 diabetes. / Inouye, Kimberly Ann S.; Bisch, Frederick C.; Elsalanty, Mohammed Elsayed; Zakhary, Ibrahim; Khashaba, Rania M.; Borke, James L.

In: Implant Dentistry, Vol. 23, No. 3, 01.01.2014, p. 319-327.

Research output: Contribution to journalArticle

Inouye, Kimberly Ann S. ; Bisch, Frederick C. ; Elsalanty, Mohammed Elsayed ; Zakhary, Ibrahim ; Khashaba, Rania M. ; Borke, James L. / Effect of metformin on periimplant wound healing in a rat model of type 2 diabetes. In: Implant Dentistry. 2014 ; Vol. 23, No. 3. pp. 319-327.
@article{8756e5f7e183405f8030bbf52512dde9,
title = "Effect of metformin on periimplant wound healing in a rat model of type 2 diabetes",
abstract = "PURPOSE:: To investigate the effects of hyperglycemia and metformin (a popular biguanide antidiabetic) on periimplant healing. METHODS:: Thirty-six male rats were assigned to 3 groups: (1) nondiabetic Wistar-Kyoto rats (controls), (2) Goto-Kakizaki (GK) spontaneously diabetic rats (GK group), and (3) GK rats were fed metformin (100 mg/kg body weight per day) in their water for 4 weeks (GK + Met group). The right maxillary first molars were extracted and sites were allowed 1 month to heal. Titanium implants (1 × 3 mm) were placed in healed extraction sites. Six rats from each group were analyzed at weeks 1 and 4 by micro computed tomography for bone/implant contact ratio, percent bone volume, trabecular number, and bone mineral density. Blood was also analyzed for glucose, HbA1c, and pyridinoline (PYD). RESULTS:: At week 1, glucose levels in the GK-Met rats were high, and all bone parameters were similar to GK rats (lower bone parameters and higher PYD than controls). At week 4, glucose levels in the GK-Met rats and all parameters were similar to controls. CONCLUSIONS:: Hyperglycemic GK type 2 diabetic rats showed improved blood glucose and wound healing around oral implants after metformin administration.",
keywords = "Dental implants, Metformin, Rat model, Type 2 diabetes",
author = "Inouye, {Kimberly Ann S.} and Bisch, {Frederick C.} and Elsalanty, {Mohammed Elsayed} and Ibrahim Zakhary and Khashaba, {Rania M.} and Borke, {James L.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1097/ID.0000000000000069",
language = "English (US)",
volume = "23",
pages = "319--327",
journal = "Implant Dentistry",
issn = "1056-6163",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Effect of metformin on periimplant wound healing in a rat model of type 2 diabetes

AU - Inouye, Kimberly Ann S.

AU - Bisch, Frederick C.

AU - Elsalanty, Mohammed Elsayed

AU - Zakhary, Ibrahim

AU - Khashaba, Rania M.

AU - Borke, James L.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - PURPOSE:: To investigate the effects of hyperglycemia and metformin (a popular biguanide antidiabetic) on periimplant healing. METHODS:: Thirty-six male rats were assigned to 3 groups: (1) nondiabetic Wistar-Kyoto rats (controls), (2) Goto-Kakizaki (GK) spontaneously diabetic rats (GK group), and (3) GK rats were fed metformin (100 mg/kg body weight per day) in their water for 4 weeks (GK + Met group). The right maxillary first molars were extracted and sites were allowed 1 month to heal. Titanium implants (1 × 3 mm) were placed in healed extraction sites. Six rats from each group were analyzed at weeks 1 and 4 by micro computed tomography for bone/implant contact ratio, percent bone volume, trabecular number, and bone mineral density. Blood was also analyzed for glucose, HbA1c, and pyridinoline (PYD). RESULTS:: At week 1, glucose levels in the GK-Met rats were high, and all bone parameters were similar to GK rats (lower bone parameters and higher PYD than controls). At week 4, glucose levels in the GK-Met rats and all parameters were similar to controls. CONCLUSIONS:: Hyperglycemic GK type 2 diabetic rats showed improved blood glucose and wound healing around oral implants after metformin administration.

AB - PURPOSE:: To investigate the effects of hyperglycemia and metformin (a popular biguanide antidiabetic) on periimplant healing. METHODS:: Thirty-six male rats were assigned to 3 groups: (1) nondiabetic Wistar-Kyoto rats (controls), (2) Goto-Kakizaki (GK) spontaneously diabetic rats (GK group), and (3) GK rats were fed metformin (100 mg/kg body weight per day) in their water for 4 weeks (GK + Met group). The right maxillary first molars were extracted and sites were allowed 1 month to heal. Titanium implants (1 × 3 mm) were placed in healed extraction sites. Six rats from each group were analyzed at weeks 1 and 4 by micro computed tomography for bone/implant contact ratio, percent bone volume, trabecular number, and bone mineral density. Blood was also analyzed for glucose, HbA1c, and pyridinoline (PYD). RESULTS:: At week 1, glucose levels in the GK-Met rats were high, and all bone parameters were similar to GK rats (lower bone parameters and higher PYD than controls). At week 4, glucose levels in the GK-Met rats and all parameters were similar to controls. CONCLUSIONS:: Hyperglycemic GK type 2 diabetic rats showed improved blood glucose and wound healing around oral implants after metformin administration.

KW - Dental implants

KW - Metformin

KW - Rat model

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=84901608730&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901608730&partnerID=8YFLogxK

U2 - 10.1097/ID.0000000000000069

DO - 10.1097/ID.0000000000000069

M3 - Article

C2 - 24776941

AN - SCOPUS:84901608730

VL - 23

SP - 319

EP - 327

JO - Implant Dentistry

JF - Implant Dentistry

SN - 1056-6163

IS - 3

ER -