Effect of oral nicardipine on anorectal function in normal human volunteers and patients with irritable bowel syndrome

W. M. Sun, C. A. Edwards, A. Prior, Satish Sanku Chander Rao, N. W. Read

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Paired controlled studies were performed in 10 normal volunteers and 32 patients with irritable bowel syndrome to investigate the effect of the calcium channel blocker nicardipine, on the responses of the anorectum to rectal distension and a meal. Nicardipine was administered orally in standard (20 mg) and sustained-release (30 mg twice a day) formulations. In normal volunteers standard nicardipine had no significant effect on the rectal responses to distension but did significantly reduce the postprandial motility index (P <0.05). In the patients with irritable bowel syndrome, standard nicardipine caused a significant reduction in distension-induced rectal motor activity (P <0.05) and increased the rectal sensory thresholds for desire to defecate and discomfort (P <0.02). Slow-release nicardipine caused a significant reduction in distension-induced activity (P <0.05) but did not alter rectal sensory thresholds. Both formulations of nicardipine significantly reduced the postprandial motility index (P <0.05) and symptoms (P <0.05). In conclusion, this study confirms that calcium channel blockers may be useful in the management of irritable bowel syndrome.

Original languageEnglish (US)
Pages (from-to)885-890
Number of pages6
JournalDigestive Diseases and Sciences
Volume35
Issue number7
DOIs
StatePublished - Jul 1 1990
Externally publishedYes

    Fingerprint

Keywords

  • irritable bowel syndrome
  • nicardipine

ASJC Scopus subject areas

  • Gastroenterology

Cite this