Effect of repeated stress on body weight and body composition of rats fed low- and high-fat diets

Ruth Babette Harris, Jun Zhou, Bradley D. Youngblood, Igor I. Rybkin, Gennady N. Smagin, Donna H. Ryan

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

Exposure to the moderate stressor of 3-h restraint for 3 consecutive days causes a temporary drop in food intake but a permanent reduction in body weight in adult rats. Young rats did not show the same response. Food intake of adult rats exposed to repeated restraint was significantly lower than that of controls for 4 days after the end of stress, and there was no rebound hyperphagia. Body weight remained significantly lower for at least 40 days after stress. When the rats were fed a high-fat diet of 80% chow and 20% vegetable shortening (48% kcal fat, 16% protein), lean body mass accounted for all of the weight loss in stressed rats. When the experiment was repeated with a purified high-fat diet containing corn oil and coconut oil as the source of fat (41% kcal fat, 16% protein), weight loss consisted of both lean and fat tissue. There were no sustained changes in single time point measures of corticosterone, insulin, or leptin that could account for the reduced body weight in these rats.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume275
Issue number6 44-6
StatePublished - Dec 1 1998
Externally publishedYes

Fingerprint

High Fat Diet
Body Composition
Fats
Body Weight
Weight Loss
Eating
Hyperphagia
Corn Oil
Corticosterone
Leptin
Vegetables
Proteins
Insulin

Keywords

  • Hormones
  • Lean body mass
  • Weight loss

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Effect of repeated stress on body weight and body composition of rats fed low- and high-fat diets. / Harris, Ruth Babette; Zhou, Jun; Youngblood, Bradley D.; Rybkin, Igor I.; Smagin, Gennady N.; Ryan, Donna H.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 275, No. 6 44-6, 01.12.1998.

Research output: Contribution to journalArticle

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