Effect of Spirulina fusiformis on cyclophosphamide and mitomycin-C induced genotoxicity and oxidative stress in mice

K. Premkumar, A. Pachiappan, Suresh K. Abraham, S. T. Santhiya, P. M. Gopinath, A. Ramesh

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

Spirulina fusiformis was tested for its possible in vivo protective effects against cyclophosphamide (CP) and mitomycin-C (MMC) induced genotoxicity and oxidative stress in mice. Pre-treatment with S. fusiformis (250, 500 and 1000 mg kg-1, p.o., daily for 5 days) significantly reduced the chromosomal damage and lipid peroxidation with concomitant changes in antioxidants and detoxification systems. All the three tested doses were effective in exerting a protective effect against CP and MMC.

Original languageEnglish (US)
Pages (from-to)906-911
Number of pages6
JournalFitoterapia
Volume72
Issue number8
DOIs
StatePublished - Dec 18 2001
Externally publishedYes

Keywords

  • Cyclophosphamide
  • Mitomycin-C
  • Protective effects
  • Spirulina fusiformis

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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