Effect of Spirulina fusiformis on cyclophosphamide and mitomycin-C induced genotoxicity and oxidative stress in mice

K. Premkumar, A. Pachiappan, Suresh K. Abraham, S. T. Santhiya, P. M. Gopinath, A. Ramesh

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Spirulina fusiformis was tested for its possible in vivo protective effects against cyclophosphamide (CP) and mitomycin-C (MMC) induced genotoxicity and oxidative stress in mice. Pre-treatment with S. fusiformis (250, 500 and 1000 mg kg-1, p.o., daily for 5 days) significantly reduced the chromosomal damage and lipid peroxidation with concomitant changes in antioxidants and detoxification systems. All the three tested doses were effective in exerting a protective effect against CP and MMC.

Original languageEnglish (US)
Pages (from-to)906-911
Number of pages6
JournalFitoterapia
Volume72
Issue number8
DOIs
StatePublished - Dec 18 2001

Fingerprint

Spirulina
Mitomycin
Cyclophosphamide
Oxidative Stress
Lipid Peroxidation
Antioxidants

Keywords

  • Cyclophosphamide
  • Mitomycin-C
  • Protective effects
  • Spirulina fusiformis

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Effect of Spirulina fusiformis on cyclophosphamide and mitomycin-C induced genotoxicity and oxidative stress in mice. / Premkumar, K.; Pachiappan, A.; Abraham, Suresh K.; Santhiya, S. T.; Gopinath, P. M.; Ramesh, A.

In: Fitoterapia, Vol. 72, No. 8, 18.12.2001, p. 906-911.

Research output: Contribution to journalArticle

Premkumar, K. ; Pachiappan, A. ; Abraham, Suresh K. ; Santhiya, S. T. ; Gopinath, P. M. ; Ramesh, A. / Effect of Spirulina fusiformis on cyclophosphamide and mitomycin-C induced genotoxicity and oxidative stress in mice. In: Fitoterapia. 2001 ; Vol. 72, No. 8. pp. 906-911.
@article{ccecc285e04c4c4e996c02d6473e9247,
title = "Effect of Spirulina fusiformis on cyclophosphamide and mitomycin-C induced genotoxicity and oxidative stress in mice",
abstract = "Spirulina fusiformis was tested for its possible in vivo protective effects against cyclophosphamide (CP) and mitomycin-C (MMC) induced genotoxicity and oxidative stress in mice. Pre-treatment with S. fusiformis (250, 500 and 1000 mg kg-1, p.o., daily for 5 days) significantly reduced the chromosomal damage and lipid peroxidation with concomitant changes in antioxidants and detoxification systems. All the three tested doses were effective in exerting a protective effect against CP and MMC.",
keywords = "Cyclophosphamide, Mitomycin-C, Protective effects, Spirulina fusiformis",
author = "K. Premkumar and A. Pachiappan and Abraham, {Suresh K.} and Santhiya, {S. T.} and Gopinath, {P. M.} and A. Ramesh",
year = "2001",
month = "12",
day = "18",
doi = "10.1016/S0367-326X(01)00340-9",
language = "English (US)",
volume = "72",
pages = "906--911",
journal = "Fitoterapia",
issn = "0367-326X",
publisher = "Elsevier",
number = "8",

}

TY - JOUR

T1 - Effect of Spirulina fusiformis on cyclophosphamide and mitomycin-C induced genotoxicity and oxidative stress in mice

AU - Premkumar, K.

AU - Pachiappan, A.

AU - Abraham, Suresh K.

AU - Santhiya, S. T.

AU - Gopinath, P. M.

AU - Ramesh, A.

PY - 2001/12/18

Y1 - 2001/12/18

N2 - Spirulina fusiformis was tested for its possible in vivo protective effects against cyclophosphamide (CP) and mitomycin-C (MMC) induced genotoxicity and oxidative stress in mice. Pre-treatment with S. fusiformis (250, 500 and 1000 mg kg-1, p.o., daily for 5 days) significantly reduced the chromosomal damage and lipid peroxidation with concomitant changes in antioxidants and detoxification systems. All the three tested doses were effective in exerting a protective effect against CP and MMC.

AB - Spirulina fusiformis was tested for its possible in vivo protective effects against cyclophosphamide (CP) and mitomycin-C (MMC) induced genotoxicity and oxidative stress in mice. Pre-treatment with S. fusiformis (250, 500 and 1000 mg kg-1, p.o., daily for 5 days) significantly reduced the chromosomal damage and lipid peroxidation with concomitant changes in antioxidants and detoxification systems. All the three tested doses were effective in exerting a protective effect against CP and MMC.

KW - Cyclophosphamide

KW - Mitomycin-C

KW - Protective effects

KW - Spirulina fusiformis

UR - http://www.scopus.com/inward/record.url?scp=0035205735&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035205735&partnerID=8YFLogxK

U2 - 10.1016/S0367-326X(01)00340-9

DO - 10.1016/S0367-326X(01)00340-9

M3 - Article

C2 - 11731115

AN - SCOPUS:0035205735

VL - 72

SP - 906

EP - 911

JO - Fitoterapia

JF - Fitoterapia

SN - 0367-326X

IS - 8

ER -