TY - JOUR
T1 - Effect of tamoxifen on plasma lipids and lipoproteins in postmenopausal women with breast cancer
AU - Thangaraju, Muthusamy
AU - Kumar, Kalyanam
AU - Gandhirajan, Rengasamy
AU - Sachdanandam, Panchanatham
PY - 1994/2/1
Y1 - 1994/2/1
N2 - Background. Adjuvant tamoxifen therapy is given to large and increasing numbers of women with early‐stage breast cancer. The effects of this drug on plasma lipids and lipoprotein profiles are important, because cardiovascular disease also develops over time in a large percentage of tamoxifen‐treated postmenopausal women. The purpose of the study was to evaluate the effects of tamoxifen on plasma lipid and lipoprotein profiles in postmenopausal Indian women who were disease‐free after primary treatment for breast cancer. Methods. A short‐term evaluation of 6 months of tamoxifen therapy (10 mg twice a day) in 45 postmenopausal women was conducted. The plasma lipids and lipoprotein levels were evaluated before and after 3 and 6 months of tamoxifen treatment. Results. At 3 and 6 months' evaluation, patients receiving tamoxifen showed significantly decreased levels of total cholesterol, free cholesterol, and low‐density lipoprotein cholesterol (P < 0.001 for each) and increased levels of plasma triglycerides, free fatty acids, very low density lipoprotein cholesterol, and high‐density lipoprotein cholesterol. Conclusion. The results suggest that tamoxifen therapy benefits postmenopausal patients with breast cancer, with likely reduction in the risk of cardiovascular disease.
AB - Background. Adjuvant tamoxifen therapy is given to large and increasing numbers of women with early‐stage breast cancer. The effects of this drug on plasma lipids and lipoprotein profiles are important, because cardiovascular disease also develops over time in a large percentage of tamoxifen‐treated postmenopausal women. The purpose of the study was to evaluate the effects of tamoxifen on plasma lipid and lipoprotein profiles in postmenopausal Indian women who were disease‐free after primary treatment for breast cancer. Methods. A short‐term evaluation of 6 months of tamoxifen therapy (10 mg twice a day) in 45 postmenopausal women was conducted. The plasma lipids and lipoprotein levels were evaluated before and after 3 and 6 months of tamoxifen treatment. Results. At 3 and 6 months' evaluation, patients receiving tamoxifen showed significantly decreased levels of total cholesterol, free cholesterol, and low‐density lipoprotein cholesterol (P < 0.001 for each) and increased levels of plasma triglycerides, free fatty acids, very low density lipoprotein cholesterol, and high‐density lipoprotein cholesterol. Conclusion. The results suggest that tamoxifen therapy benefits postmenopausal patients with breast cancer, with likely reduction in the risk of cardiovascular disease.
KW - breast cancer
KW - cardiovascular disease
KW - lipids
KW - lipoproteins
KW - postmenopausal women
KW - tamoxifen
UR - http://www.scopus.com/inward/record.url?scp=0027955643&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027955643&partnerID=8YFLogxK
U2 - 10.1002/1097-0142(19940201)73:3<659::AID-CNCR2820730325>3.0.CO;2-H
DO - 10.1002/1097-0142(19940201)73:3<659::AID-CNCR2820730325>3.0.CO;2-H
M3 - Article
C2 - 8299087
AN - SCOPUS:0027955643
SN - 0008-543X
VL - 73
SP - 659
EP - 663
JO - Cancer
JF - Cancer
IS - 3
ER -