Effect of tardive dyskinesia on quality of life in patients with bipolar disorder, major depressive disorder, and schizophrenia

Joseph McEvoy, Sanjay K. Gandhi, Avery A. Rizio, Stephen Maher, Mark Kosinski, Jakob Bue Bjorner, Benjamin Carroll

Research output: Contribution to journalArticle

Abstract

Purpose: Tardive dyskinesia (TD) is a common but serious hyperkinetic movement disorder and side effect of antipsychotic medications used to treat bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SZ). The purpose of this study was to evaluate health-related quality of life (HRQoL) in a population with diagnoses for BD, MDD, or SZ by comparing patients with TD (n = 197) with those without TD (n = 219). HRQoL in each group was also compared with HRQoL of the general population. Methods: This study employed a cross-sectional web-based survey. HRQoL was assessed by four instruments: the SF-12 Health Survey, Version 2 (SF-12v2), the Quality of Life Enjoyment and Satisfaction Questionnaire, Short Form (Q-LES-Q-SF), the Social Withdrawal subscale of the Internalized Stigma of Mental Illness Scale (SW-ISMI); and two questions on movement disorders. Results: Patients with TD had significantly worse HRQoL and social withdrawal than those without. The differences were more pronounced for physical HRQoL domains than for mental health domains. Patients with more-severe TD, assessed through either self-rating or clinician rating, experienced significantly worse HRQoL than did those with less-severe TD. The impact of TD was substantially greater in patients with SZ than in those with BD or MDD. Compared with the general population, patients with BD, MDD, or SZ experienced significantly worse HRQoL regardless of TD status, although this deficit in HRQoL was greater among those with TD. Conclusions: The presence of TD is associated with worse HRQoL and social withdrawal. The most severe impact of TD is on physical aspects of patients’ HRQoL.

Original languageEnglish (US)
Pages (from-to)3303-3312
Number of pages10
JournalQuality of Life Research
Volume28
Issue number12
DOIs
StatePublished - Dec 1 2019

Fingerprint

Major Depressive Disorder
Bipolar Disorder
Schizophrenia
Quality of Life
Movement Disorders
Tardive Dyskinesia
Population
Hyperkinesis
Health Surveys
Antipsychotic Agents
Mental Health

Keywords

  • Bipolar disorder
  • Health-related quality of life
  • Major depressive disorder
  • Patient-reported outcome
  • Schizophrenia
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Effect of tardive dyskinesia on quality of life in patients with bipolar disorder, major depressive disorder, and schizophrenia. / McEvoy, Joseph; Gandhi, Sanjay K.; Rizio, Avery A.; Maher, Stephen; Kosinski, Mark; Bjorner, Jakob Bue; Carroll, Benjamin.

In: Quality of Life Research, Vol. 28, No. 12, 01.12.2019, p. 3303-3312.

Research output: Contribution to journalArticle

McEvoy, Joseph ; Gandhi, Sanjay K. ; Rizio, Avery A. ; Maher, Stephen ; Kosinski, Mark ; Bjorner, Jakob Bue ; Carroll, Benjamin. / Effect of tardive dyskinesia on quality of life in patients with bipolar disorder, major depressive disorder, and schizophrenia. In: Quality of Life Research. 2019 ; Vol. 28, No. 12. pp. 3303-3312.
@article{59d74da2995845718a6231854d32baeb,
title = "Effect of tardive dyskinesia on quality of life in patients with bipolar disorder, major depressive disorder, and schizophrenia",
abstract = "Purpose: Tardive dyskinesia (TD) is a common but serious hyperkinetic movement disorder and side effect of antipsychotic medications used to treat bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SZ). The purpose of this study was to evaluate health-related quality of life (HRQoL) in a population with diagnoses for BD, MDD, or SZ by comparing patients with TD (n = 197) with those without TD (n = 219). HRQoL in each group was also compared with HRQoL of the general population. Methods: This study employed a cross-sectional web-based survey. HRQoL was assessed by four instruments: the SF-12 Health Survey, Version 2 (SF-12v2), the Quality of Life Enjoyment and Satisfaction Questionnaire, Short Form (Q-LES-Q-SF), the Social Withdrawal subscale of the Internalized Stigma of Mental Illness Scale (SW-ISMI); and two questions on movement disorders. Results: Patients with TD had significantly worse HRQoL and social withdrawal than those without. The differences were more pronounced for physical HRQoL domains than for mental health domains. Patients with more-severe TD, assessed through either self-rating or clinician rating, experienced significantly worse HRQoL than did those with less-severe TD. The impact of TD was substantially greater in patients with SZ than in those with BD or MDD. Compared with the general population, patients with BD, MDD, or SZ experienced significantly worse HRQoL regardless of TD status, although this deficit in HRQoL was greater among those with TD. Conclusions: The presence of TD is associated with worse HRQoL and social withdrawal. The most severe impact of TD is on physical aspects of patients’ HRQoL.",
keywords = "Bipolar disorder, Health-related quality of life, Major depressive disorder, Patient-reported outcome, Schizophrenia, Tardive dyskinesia",
author = "Joseph McEvoy and Gandhi, {Sanjay K.} and Rizio, {Avery A.} and Stephen Maher and Mark Kosinski and Bjorner, {Jakob Bue} and Benjamin Carroll",
year = "2019",
month = "12",
day = "1",
doi = "10.1007/s11136-019-02269-8",
language = "English (US)",
volume = "28",
pages = "3303--3312",
journal = "Quality of Life Research",
issn = "0962-9343",
publisher = "Springer Netherlands",
number = "12",

}

TY - JOUR

T1 - Effect of tardive dyskinesia on quality of life in patients with bipolar disorder, major depressive disorder, and schizophrenia

AU - McEvoy, Joseph

AU - Gandhi, Sanjay K.

AU - Rizio, Avery A.

AU - Maher, Stephen

AU - Kosinski, Mark

AU - Bjorner, Jakob Bue

AU - Carroll, Benjamin

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Purpose: Tardive dyskinesia (TD) is a common but serious hyperkinetic movement disorder and side effect of antipsychotic medications used to treat bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SZ). The purpose of this study was to evaluate health-related quality of life (HRQoL) in a population with diagnoses for BD, MDD, or SZ by comparing patients with TD (n = 197) with those without TD (n = 219). HRQoL in each group was also compared with HRQoL of the general population. Methods: This study employed a cross-sectional web-based survey. HRQoL was assessed by four instruments: the SF-12 Health Survey, Version 2 (SF-12v2), the Quality of Life Enjoyment and Satisfaction Questionnaire, Short Form (Q-LES-Q-SF), the Social Withdrawal subscale of the Internalized Stigma of Mental Illness Scale (SW-ISMI); and two questions on movement disorders. Results: Patients with TD had significantly worse HRQoL and social withdrawal than those without. The differences were more pronounced for physical HRQoL domains than for mental health domains. Patients with more-severe TD, assessed through either self-rating or clinician rating, experienced significantly worse HRQoL than did those with less-severe TD. The impact of TD was substantially greater in patients with SZ than in those with BD or MDD. Compared with the general population, patients with BD, MDD, or SZ experienced significantly worse HRQoL regardless of TD status, although this deficit in HRQoL was greater among those with TD. Conclusions: The presence of TD is associated with worse HRQoL and social withdrawal. The most severe impact of TD is on physical aspects of patients’ HRQoL.

AB - Purpose: Tardive dyskinesia (TD) is a common but serious hyperkinetic movement disorder and side effect of antipsychotic medications used to treat bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SZ). The purpose of this study was to evaluate health-related quality of life (HRQoL) in a population with diagnoses for BD, MDD, or SZ by comparing patients with TD (n = 197) with those without TD (n = 219). HRQoL in each group was also compared with HRQoL of the general population. Methods: This study employed a cross-sectional web-based survey. HRQoL was assessed by four instruments: the SF-12 Health Survey, Version 2 (SF-12v2), the Quality of Life Enjoyment and Satisfaction Questionnaire, Short Form (Q-LES-Q-SF), the Social Withdrawal subscale of the Internalized Stigma of Mental Illness Scale (SW-ISMI); and two questions on movement disorders. Results: Patients with TD had significantly worse HRQoL and social withdrawal than those without. The differences were more pronounced for physical HRQoL domains than for mental health domains. Patients with more-severe TD, assessed through either self-rating or clinician rating, experienced significantly worse HRQoL than did those with less-severe TD. The impact of TD was substantially greater in patients with SZ than in those with BD or MDD. Compared with the general population, patients with BD, MDD, or SZ experienced significantly worse HRQoL regardless of TD status, although this deficit in HRQoL was greater among those with TD. Conclusions: The presence of TD is associated with worse HRQoL and social withdrawal. The most severe impact of TD is on physical aspects of patients’ HRQoL.

KW - Bipolar disorder

KW - Health-related quality of life

KW - Major depressive disorder

KW - Patient-reported outcome

KW - Schizophrenia

KW - Tardive dyskinesia

UR - http://www.scopus.com/inward/record.url?scp=85071293361&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071293361&partnerID=8YFLogxK

U2 - 10.1007/s11136-019-02269-8

DO - 10.1007/s11136-019-02269-8

M3 - Article

C2 - 31435866

AN - SCOPUS:85071293361

VL - 28

SP - 3303

EP - 3312

JO - Quality of Life Research

JF - Quality of Life Research

SN - 0962-9343

IS - 12

ER -