Effect of testosterone on the apneic threshold in women during NREM sleep

X. S. Zhou, J. A. Rowley, F. Demirovic, Michael Peter Diamond, M. S. Badr

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

The hypocapnic apneic threshold (AT) is lower in women relative to men. To test the hypothesis that the gender difference in AT was due to testosterone, we determined the AT during non-rapid eye movement sleep in eight healthy, nonsnoring, premenopausal women before and after 10-12 days of transdermal testosterone. Hypocapnia was induced via nasal mechanical ventilation (MV) for 3 min with tidal volumes ranging from 175 to 215% above eupneic tidal volume and respiratory frequency matched to eupneic frequency. Cessation of MV resulted in hypocapnic central apnea or hypopnea depending on the magnitude of hypocapnia. Nadir minute ventilation as a percentage of control (%VE) was plotted against the change in end-tidal CO2 (PETCO2); %VE was given a value of zero during central apnea. The AT was defined as the PETCO2 at which the apnea closest to the last hypopnea occurred; hypocapnic ventilatory response (HPVR) was defined as the slope of the linear regression VE vs. PETCO2. Both the AT (39.5 ± 2.9 vs. 42.1 ± 3.0 Torr; P = 0.002) and HPVR (0.20 ± 0.05 vs. 0.33 ± 0.11%VE/Torr; P = 0.016) increased with testosterone administration. We conclude that testosterone administration increases AT in premenopausal women, suggesting that the increased breathing instability during sleep in men is related to the presence of testosterone.

Original languageEnglish (US)
Pages (from-to)101-107
Number of pages7
JournalJournal of Applied Physiology
Volume94
Issue number1
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

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Testosterone
Sleep
Central Sleep Apnea
Hypocapnia
Tidal Volume
Artificial Respiration
Apnea
Eye Movements
Nose
Ventilation
Linear Models
Respiration

Keywords

  • Control of breathing
  • Gender
  • Hypocapnia

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Effect of testosterone on the apneic threshold in women during NREM sleep. / Zhou, X. S.; Rowley, J. A.; Demirovic, F.; Diamond, Michael Peter; Badr, M. S.

In: Journal of Applied Physiology, Vol. 94, No. 1, 01.01.2003, p. 101-107.

Research output: Contribution to journalArticle

Zhou, X. S. ; Rowley, J. A. ; Demirovic, F. ; Diamond, Michael Peter ; Badr, M. S. / Effect of testosterone on the apneic threshold in women during NREM sleep. In: Journal of Applied Physiology. 2003 ; Vol. 94, No. 1. pp. 101-107.
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