Effect of the baseline pulse wave velocity on short term and long term blood pressure control in primary hypertension

Y. Fan, W. Gao, J. Li, F. Fan, X. Qin, L. Liu, X. Cheng, X. Xu, X. Wang, B. Wang, Y. Huo

Research output: Contribution to journalArticle

Abstract

Objectives: Arterial stiffness may affect antihypertensive response to antihypertensive treatment. However, sufficient clinical evidence is lacking. This longitudinal study aimed to evaluate the effect of baseline arterial stiffness measured by the brachial-ankle pulse wave velocity (baPWV) on response to short-term and long-term enalapril-based treatment in 3310 hypertensive adults from the China Stroke Primary Prevention Trial (CSPPT). Methods and results: Blood pressure (BP) measured at three months (short-term) in 2780 subjects, and the time-average on-treatment BP in 3310 subjects during a median of 4.5-year follow-ups (long-term) were analyzed in the study. After short-term antihypertensive treatment, every 1 m/s increase in baPWV denoted a 7% and 6% decreased chance of achieving systolic BP (SBP) control (odds ratio (OR), 0.93; 95% CI 0.90, 0.96; P < 0.001) and BP control (OR, 0.94; 95% CI 0.91, 0.97; P < 0.001), respectively, after adjustment for age, gender and other variables. After long-term treatment, every 1 m/s increase in baPWV posed an 7% and 6% greater risk of failing to attain SBP control (OR, 0.93; 95% CI 0.90, 0.95; P < 0.001) and BP control (OR, 0.94; 95% CI, 0.92, 0.96; P < 0.001), respectively, not regarding for DBP control after both short- and long-term treatment. Higher baseline baPWV significantly decreased SBP reduction both after three months and the median 4.5-year treatment, while increased DBP reduction after the median 4.5-year treatment. Conclusions: Elevated baseline baPWV significantly decreased BP response to short-and long-term treatment in adults with primary hypertensive. Arterial stiffness improvement may be an essential target to achieve adequate BP control.

Original languageEnglish (US)
Pages (from-to)193-199
Number of pages7
JournalInternational Journal of Cardiology
Volume317
DOIs
StateAccepted/In press - 2020

Keywords

  • Arterial stiffness
  • Blood pressure control
  • Brachial-ankle pulse wave velocity
  • Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Effect of the baseline pulse wave velocity on short term and long term blood pressure control in primary hypertension'. Together they form a unique fingerprint.

  • Cite this