Effect of variable moderate chronic stress on ligature-induced periodontal disease in Wistar rats

Cristiano Susin, Cassiano Kuchenbecker Rösing

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14 Scopus citations

Abstract

The aim of this investigation was to study the impact of stress on ligature-induced periodontal disease in rats by means of a variable moderate chronic stress model. Thirty male Wistar rats were randomly assigned to six groups. Control groups received only ligatures around the second maxillary molars, while experimental groups were exposed to stress in additional. Stress was imposed by means of flashing light, isolation, rat blood smelling, new environment exposure, immobilization in cold temperature and immobilization at room temperature. Stress was applied randomly, thereby diminishing adaptation of the animals to the model. The animals were killed after 29, 43, and 57 days. The distance between the cementum-enamel junction and the alveolar bone (CEJ-AB) was measured. Alveolar bone loss was statistically different between stressed and control animals, whereas differences were not observed between experimental periods. The mean CEJ-AB distance in animals exposed to stress was 154.50 μm smaller than the corresponding distance in the controls. It might be concluded that variable moderate chronic stress decreased alveolar bone loss in a ligature-induced periodontal disease model.

Original languageEnglish (US)
Pages (from-to)273-277
Number of pages5
JournalActa Odontologica Scandinavica
Volume61
Issue number5
DOIs
StatePublished - Oct 1 2003

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Keywords

  • Alveolar bone loss
  • Periodontal diseases
  • Rat
  • Stress

ASJC Scopus subject areas

  • Dentistry(all)

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