Effect of variable moderate chronic stress on ligature-induced periodontal disease in Wistar rats

Cristiano Susin, Cassiano Kuchenbecker Rösing

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The aim of this investigation was to study the impact of stress on ligature-induced periodontal disease in rats by means of a variable moderate chronic stress model. Thirty male Wistar rats were randomly assigned to six groups. Control groups received only ligatures around the second maxillary molars, while experimental groups were exposed to stress in additional. Stress was imposed by means of flashing light, isolation, rat blood smelling, new environment exposure, immobilization in cold temperature and immobilization at room temperature. Stress was applied randomly, thereby diminishing adaptation of the animals to the model. The animals were killed after 29, 43, and 57 days. The distance between the cementum-enamel junction and the alveolar bone (CEJ-AB) was measured. Alveolar bone loss was statistically different between stressed and control animals, whereas differences were not observed between experimental periods. The mean CEJ-AB distance in animals exposed to stress was 154.50 μm smaller than the corresponding distance in the controls. It might be concluded that variable moderate chronic stress decreased alveolar bone loss in a ligature-induced periodontal disease model.

Original languageEnglish (US)
Pages (from-to)273-277
Number of pages5
JournalActa Odontologica Scandinavica
Volume61
Issue number5
DOIs
StatePublished - Oct 1 2003

Fingerprint

Periodontal Diseases
Alveolar Bone Loss
Ligation
Dental Cementum
Wistar Rats
Dental Enamel
Immobilization
Bone and Bones
Animal Models
Light
Control Groups
Temperature

Keywords

  • Alveolar bone loss
  • Periodontal diseases
  • Rat
  • Stress

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Effect of variable moderate chronic stress on ligature-induced periodontal disease in Wistar rats. / Susin, Cristiano; Rösing, Cassiano Kuchenbecker.

In: Acta Odontologica Scandinavica, Vol. 61, No. 5, 01.10.2003, p. 273-277.

Research output: Contribution to journalArticle

Susin, Cristiano ; Rösing, Cassiano Kuchenbecker. / Effect of variable moderate chronic stress on ligature-induced periodontal disease in Wistar rats. In: Acta Odontologica Scandinavica. 2003 ; Vol. 61, No. 5. pp. 273-277.
@article{a6606c79923743919b6e998b009f7885,
title = "Effect of variable moderate chronic stress on ligature-induced periodontal disease in Wistar rats",
abstract = "The aim of this investigation was to study the impact of stress on ligature-induced periodontal disease in rats by means of a variable moderate chronic stress model. Thirty male Wistar rats were randomly assigned to six groups. Control groups received only ligatures around the second maxillary molars, while experimental groups were exposed to stress in additional. Stress was imposed by means of flashing light, isolation, rat blood smelling, new environment exposure, immobilization in cold temperature and immobilization at room temperature. Stress was applied randomly, thereby diminishing adaptation of the animals to the model. The animals were killed after 29, 43, and 57 days. The distance between the cementum-enamel junction and the alveolar bone (CEJ-AB) was measured. Alveolar bone loss was statistically different between stressed and control animals, whereas differences were not observed between experimental periods. The mean CEJ-AB distance in animals exposed to stress was 154.50 μm smaller than the corresponding distance in the controls. It might be concluded that variable moderate chronic stress decreased alveolar bone loss in a ligature-induced periodontal disease model.",
keywords = "Alveolar bone loss, Periodontal diseases, Rat, Stress",
author = "Cristiano Susin and R{\"o}sing, {Cassiano Kuchenbecker}",
year = "2003",
month = "10",
day = "1",
doi = "10.1080/00016350310005574",
language = "English (US)",
volume = "61",
pages = "273--277",
journal = "Acta Odontologica Scandinavica",
issn = "0001-6357",
publisher = "Informa Healthcare",
number = "5",

}

TY - JOUR

T1 - Effect of variable moderate chronic stress on ligature-induced periodontal disease in Wistar rats

AU - Susin, Cristiano

AU - Rösing, Cassiano Kuchenbecker

PY - 2003/10/1

Y1 - 2003/10/1

N2 - The aim of this investigation was to study the impact of stress on ligature-induced periodontal disease in rats by means of a variable moderate chronic stress model. Thirty male Wistar rats were randomly assigned to six groups. Control groups received only ligatures around the second maxillary molars, while experimental groups were exposed to stress in additional. Stress was imposed by means of flashing light, isolation, rat blood smelling, new environment exposure, immobilization in cold temperature and immobilization at room temperature. Stress was applied randomly, thereby diminishing adaptation of the animals to the model. The animals were killed after 29, 43, and 57 days. The distance between the cementum-enamel junction and the alveolar bone (CEJ-AB) was measured. Alveolar bone loss was statistically different between stressed and control animals, whereas differences were not observed between experimental periods. The mean CEJ-AB distance in animals exposed to stress was 154.50 μm smaller than the corresponding distance in the controls. It might be concluded that variable moderate chronic stress decreased alveolar bone loss in a ligature-induced periodontal disease model.

AB - The aim of this investigation was to study the impact of stress on ligature-induced periodontal disease in rats by means of a variable moderate chronic stress model. Thirty male Wistar rats were randomly assigned to six groups. Control groups received only ligatures around the second maxillary molars, while experimental groups were exposed to stress in additional. Stress was imposed by means of flashing light, isolation, rat blood smelling, new environment exposure, immobilization in cold temperature and immobilization at room temperature. Stress was applied randomly, thereby diminishing adaptation of the animals to the model. The animals were killed after 29, 43, and 57 days. The distance between the cementum-enamel junction and the alveolar bone (CEJ-AB) was measured. Alveolar bone loss was statistically different between stressed and control animals, whereas differences were not observed between experimental periods. The mean CEJ-AB distance in animals exposed to stress was 154.50 μm smaller than the corresponding distance in the controls. It might be concluded that variable moderate chronic stress decreased alveolar bone loss in a ligature-induced periodontal disease model.

KW - Alveolar bone loss

KW - Periodontal diseases

KW - Rat

KW - Stress

UR - http://www.scopus.com/inward/record.url?scp=10744220723&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10744220723&partnerID=8YFLogxK

U2 - 10.1080/00016350310005574

DO - 10.1080/00016350310005574

M3 - Article

C2 - 14763778

AN - SCOPUS:10744220723

VL - 61

SP - 273

EP - 277

JO - Acta Odontologica Scandinavica

JF - Acta Odontologica Scandinavica

SN - 0001-6357

IS - 5

ER -