Effect of vitamin D supplementation on markers of vascular function

A systematic review and individual participant meta- analysis

Louise A. Beveridge, Faisel Khan, Allan D. Struthers, Jane Armitage, Ilaria Barchetta, Iain Bressendorff, Maria Gisella Cavallo, Robert Clarke, Rinkoo Dalan, Gavin Dreyer, Adam D. Gepner, Nita G. Forouhi, Ryan A. Harris, Graham A. Hitman, Thomas Larsen, Rajesh Khadgawat, Peter Marckmann, Frank H. Mose, Stefan Pilz, Alexandra Scholze & 5 others Marina Shargorodsky, Seth I. Sokol, Hans Stricker, Carmine Zoccali, Miles D. Witham

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background--Low 25-hydroxyvitamin D levels are associated with an increased risk of cardiovascular events, but the effect of vitamin D supplementation on markers of vascular function associated with major adverse cardiovascular events is unclear. Methods and Results--We conducted a systematic review and individual participant meta-analysis to examine the effect of vitamin D supplementation on flow-mediated dilatation of the brachial artery, pulse wave velocity, augmentation index, central blood pressure, microvascular function, and reactive hyperemia index. MEDLINE, CINAHL, EMBASE, Cochrane Central Register of Controlled Trials, and http://www.ClinicalTrials.gov were searched until the end of 2016 without language restrictions. Placebo-controlled randomized trials of at least4 weeks duration were included. Individual participant data were sought from investigators on included trials. Trial-level metaanalysis was performed using random-effects models; individual participant meta-analyses used a 2-stage analytic strategy, examining effects in prespecified subgroups. 31trials (2751 participants) were included; 29 trials (2641participants) contributed data to trial-level meta-analysis, and24trials (2051 participants) contributed to individual-participant analyses. VitaminD3daily dose equivalents ranged from 900 to 5000 IU; duration was 4 weeks to12 months. Trial-level meta-analysis showed no significant effect of supplementation on macrovascularmeasures(flow-mediateddilatation,0.37%[95%confidenceinterval,-0.23to0.97]; carotid-femoralpulsewavevelocity, 0.00 m/s [95% confidence interval, -0.36 to 0.37]); similar results were obtained from individual participant data. Microvascular function showed a modest improvement in trial-level data only. No consistent benefit was observed in subgroup analyses or between different vitamin D analogues. Conclusions--Vitamin D supplementation had no significant effect on most markers of vascular function in this analysis.

Original languageEnglish (US)
Article numbere008273
JournalJournal of the American Heart Association
Volume7
Issue number11
DOIs
StatePublished - Jun 1 2018

Fingerprint

Vitamin D
Blood Vessels
Meta-Analysis
Pulse Wave Analysis
Brachial Artery
Hyperemia
MEDLINE
Dilatation
Language
Randomized Controlled Trials
Placebos
Research Personnel
Confidence Intervals
Blood Pressure

Keywords

  • Endothelial function
  • Paricalcitol
  • Systematic review
  • Vascular function
  • Vitamin D

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Beveridge, L. A., Khan, F., Struthers, A. D., Armitage, J., Barchetta, I., Bressendorff, I., ... Witham, M. D. (2018). Effect of vitamin D supplementation on markers of vascular function: A systematic review and individual participant meta- analysis. Journal of the American Heart Association, 7(11), [e008273]. https://doi.org/10.1161/JAHA.117.008273

Effect of vitamin D supplementation on markers of vascular function : A systematic review and individual participant meta- analysis. / Beveridge, Louise A.; Khan, Faisel; Struthers, Allan D.; Armitage, Jane; Barchetta, Ilaria; Bressendorff, Iain; Cavallo, Maria Gisella; Clarke, Robert; Dalan, Rinkoo; Dreyer, Gavin; Gepner, Adam D.; Forouhi, Nita G.; Harris, Ryan A.; Hitman, Graham A.; Larsen, Thomas; Khadgawat, Rajesh; Marckmann, Peter; Mose, Frank H.; Pilz, Stefan; Scholze, Alexandra; Shargorodsky, Marina; Sokol, Seth I.; Stricker, Hans; Zoccali, Carmine; Witham, Miles D.

In: Journal of the American Heart Association, Vol. 7, No. 11, e008273, 01.06.2018.

Research output: Contribution to journalArticle

Beveridge, LA, Khan, F, Struthers, AD, Armitage, J, Barchetta, I, Bressendorff, I, Cavallo, MG, Clarke, R, Dalan, R, Dreyer, G, Gepner, AD, Forouhi, NG, Harris, RA, Hitman, GA, Larsen, T, Khadgawat, R, Marckmann, P, Mose, FH, Pilz, S, Scholze, A, Shargorodsky, M, Sokol, SI, Stricker, H, Zoccali, C & Witham, MD 2018, 'Effect of vitamin D supplementation on markers of vascular function: A systematic review and individual participant meta- analysis', Journal of the American Heart Association, vol. 7, no. 11, e008273. https://doi.org/10.1161/JAHA.117.008273
Beveridge, Louise A. ; Khan, Faisel ; Struthers, Allan D. ; Armitage, Jane ; Barchetta, Ilaria ; Bressendorff, Iain ; Cavallo, Maria Gisella ; Clarke, Robert ; Dalan, Rinkoo ; Dreyer, Gavin ; Gepner, Adam D. ; Forouhi, Nita G. ; Harris, Ryan A. ; Hitman, Graham A. ; Larsen, Thomas ; Khadgawat, Rajesh ; Marckmann, Peter ; Mose, Frank H. ; Pilz, Stefan ; Scholze, Alexandra ; Shargorodsky, Marina ; Sokol, Seth I. ; Stricker, Hans ; Zoccali, Carmine ; Witham, Miles D. / Effect of vitamin D supplementation on markers of vascular function : A systematic review and individual participant meta- analysis. In: Journal of the American Heart Association. 2018 ; Vol. 7, No. 11.
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abstract = "Background--Low 25-hydroxyvitamin D levels are associated with an increased risk of cardiovascular events, but the effect of vitamin D supplementation on markers of vascular function associated with major adverse cardiovascular events is unclear. Methods and Results--We conducted a systematic review and individual participant meta-analysis to examine the effect of vitamin D supplementation on flow-mediated dilatation of the brachial artery, pulse wave velocity, augmentation index, central blood pressure, microvascular function, and reactive hyperemia index. MEDLINE, CINAHL, EMBASE, Cochrane Central Register of Controlled Trials, and http://www.ClinicalTrials.gov were searched until the end of 2016 without language restrictions. Placebo-controlled randomized trials of at least4 weeks duration were included. Individual participant data were sought from investigators on included trials. Trial-level metaanalysis was performed using random-effects models; individual participant meta-analyses used a 2-stage analytic strategy, examining effects in prespecified subgroups. 31trials (2751 participants) were included; 29 trials (2641participants) contributed data to trial-level meta-analysis, and24trials (2051 participants) contributed to individual-participant analyses. VitaminD3daily dose equivalents ranged from 900 to 5000 IU; duration was 4 weeks to12 months. Trial-level meta-analysis showed no significant effect of supplementation on macrovascularmeasures(flow-mediateddilatation,0.37{\%}[95{\%}confidenceinterval,-0.23to0.97]; carotid-femoralpulsewavevelocity, 0.00 m/s [95{\%} confidence interval, -0.36 to 0.37]); similar results were obtained from individual participant data. Microvascular function showed a modest improvement in trial-level data only. No consistent benefit was observed in subgroup analyses or between different vitamin D analogues. Conclusions--Vitamin D supplementation had no significant effect on most markers of vascular function in this analysis.",
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AU - Beveridge, Louise A.

AU - Khan, Faisel

AU - Struthers, Allan D.

AU - Armitage, Jane

AU - Barchetta, Ilaria

AU - Bressendorff, Iain

AU - Cavallo, Maria Gisella

AU - Clarke, Robert

AU - Dalan, Rinkoo

AU - Dreyer, Gavin

AU - Gepner, Adam D.

AU - Forouhi, Nita G.

AU - Harris, Ryan A.

AU - Hitman, Graham A.

AU - Larsen, Thomas

AU - Khadgawat, Rajesh

AU - Marckmann, Peter

AU - Mose, Frank H.

AU - Pilz, Stefan

AU - Scholze, Alexandra

AU - Shargorodsky, Marina

AU - Sokol, Seth I.

AU - Stricker, Hans

AU - Zoccali, Carmine

AU - Witham, Miles D.

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N2 - Background--Low 25-hydroxyvitamin D levels are associated with an increased risk of cardiovascular events, but the effect of vitamin D supplementation on markers of vascular function associated with major adverse cardiovascular events is unclear. Methods and Results--We conducted a systematic review and individual participant meta-analysis to examine the effect of vitamin D supplementation on flow-mediated dilatation of the brachial artery, pulse wave velocity, augmentation index, central blood pressure, microvascular function, and reactive hyperemia index. MEDLINE, CINAHL, EMBASE, Cochrane Central Register of Controlled Trials, and http://www.ClinicalTrials.gov were searched until the end of 2016 without language restrictions. Placebo-controlled randomized trials of at least4 weeks duration were included. Individual participant data were sought from investigators on included trials. Trial-level metaanalysis was performed using random-effects models; individual participant meta-analyses used a 2-stage analytic strategy, examining effects in prespecified subgroups. 31trials (2751 participants) were included; 29 trials (2641participants) contributed data to trial-level meta-analysis, and24trials (2051 participants) contributed to individual-participant analyses. VitaminD3daily dose equivalents ranged from 900 to 5000 IU; duration was 4 weeks to12 months. Trial-level meta-analysis showed no significant effect of supplementation on macrovascularmeasures(flow-mediateddilatation,0.37%[95%confidenceinterval,-0.23to0.97]; carotid-femoralpulsewavevelocity, 0.00 m/s [95% confidence interval, -0.36 to 0.37]); similar results were obtained from individual participant data. Microvascular function showed a modest improvement in trial-level data only. No consistent benefit was observed in subgroup analyses or between different vitamin D analogues. Conclusions--Vitamin D supplementation had no significant effect on most markers of vascular function in this analysis.

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