Effect of water-aging on the antimicrobial activities of an ORMOSIL-containing orthodontic acrylic resin

Shi Qiang Gong, D. Jeevanie Epasinghe, Bin Zhou, Li Na Niu, Kirk A. Kimmerling, Frederick Rueggeberg, Cynthia K.Y. Yiu, Jing Mao, David Henry Pashley, Franklin Chi Meng Tay

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Quaternary ammonium methacryloxy silicate (QAMS), an organically modified silicate (ORMOSIL) functionalized with polymerizable methacrylate groups and an antimicrobial agent with a long lipophilic alkyl chain quaternary ammonium group, was synthesized through a silane-based sol-gel route. By dissolving QAMS in methyl methacrylate monomer, this ORMOSIL molecule was incorporated into an auto-polymerizing, powder/liquid orthodontic acrylic resin system, yielding QAMS-containing poly(methyl methacrylate). The QAMS-containing acrylic resin showed a predominant contact-killing effect on Streptococcus mutans (ATCC 35668) and Actinomyces naeslundii (ATCC 12104) biofilms, while inhibiting adhesion of Candida albicans (ATCC 90028) on the acrylic surface. The antimicrobial activities of QAMS-containing acrylic resin were maintained after a 3 month water-aging period. Bromophenol blue assay showed minimal leaching of quaternary ammonium species when an appropriate amount of QAMS (<4 wt.%) was incorporated into the acrylic resin. The results suggest that QAMS is predominantly co-polymerized with the poly(methyl methacrylate) network, and only a minuscule amount of free QAMS molecules is present within the polymer network after water-aging. Acrylic resin with persistent antimicrobial activities represents a promising method for preventing bacteria- and fungus-induced stomatitis, an infectious disease commonly associated with the wearing of removable orthodontic appliances.

Original languageEnglish (US)
Pages (from-to)6964-6973
Number of pages10
JournalActa biomaterialia
Volume9
Issue number6
DOIs
StatePublished - Jun 1 2013

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Acrylic Resins
Silicates
Orthodontics
Ammonium Compounds
Acrylics
Resins
Aging of materials
Water
Polymethyl Methacrylate
Polymethyl methacrylates
Removable Orthodontic Appliances
Bromphenol Blue
Methylmethacrylate
Antimicrobial agents
Silanes
Actinomyces
Stomatitis
Molecules
Streptococcus mutans
Methacrylates

Keywords

  • Antimicrobial
  • Biofilm
  • Ormosil
  • Orthodontic base polymer
  • Polymethyl methacrylate

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

Cite this

Effect of water-aging on the antimicrobial activities of an ORMOSIL-containing orthodontic acrylic resin. / Gong, Shi Qiang; Epasinghe, D. Jeevanie; Zhou, Bin; Niu, Li Na; Kimmerling, Kirk A.; Rueggeberg, Frederick; Yiu, Cynthia K.Y.; Mao, Jing; Pashley, David Henry; Tay, Franklin Chi Meng.

In: Acta biomaterialia, Vol. 9, No. 6, 01.06.2013, p. 6964-6973.

Research output: Contribution to journalArticle

Gong, SQ, Epasinghe, DJ, Zhou, B, Niu, LN, Kimmerling, KA, Rueggeberg, F, Yiu, CKY, Mao, J, Pashley, DH & Tay, FCM 2013, 'Effect of water-aging on the antimicrobial activities of an ORMOSIL-containing orthodontic acrylic resin', Acta biomaterialia, vol. 9, no. 6, pp. 6964-6973. https://doi.org/10.1016/j.actbio.2013.02.031
Gong, Shi Qiang ; Epasinghe, D. Jeevanie ; Zhou, Bin ; Niu, Li Na ; Kimmerling, Kirk A. ; Rueggeberg, Frederick ; Yiu, Cynthia K.Y. ; Mao, Jing ; Pashley, David Henry ; Tay, Franklin Chi Meng. / Effect of water-aging on the antimicrobial activities of an ORMOSIL-containing orthodontic acrylic resin. In: Acta biomaterialia. 2013 ; Vol. 9, No. 6. pp. 6964-6973.
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