Effective restoration of dystrophin expression in iPSC ^Mdx-derived muscle progenitor cells using the CRISPR/Cas9 system and homology-directed repair technology

Medicine & Life Sciences

• Dystrophin 88%
• Clustered Regularly Interspaced Short Palindromic Repeats 81%
• Induced Pluripotent Stem Cells 80%
• Muscle Cells 65%
• Stem Cells 52%
• Exons 51%
• Technology 46%
• Duchenne Muscular Dystrophy 41%
• Genes 17%
• Clone Cells 14%
• Clonal Deletion 13%
• Inbred mdx Mouse 12%
• Gene Editing 10%
• Muscles 10%
• Doxycycline 10%
• Genetic Recombination 8%
• Cell- and Tissue-Based Therapy 8%
• Proteins 6%
• Anti-Bacterial Agents 5%
• Gene Expression 5%
• Mutation 4%
• In Vitro Techniques 3%

Engineering & Materials Science

• Stem cells 100%
• Restoration 69%
• Muscle 65%
• Repair 57%
• Genes 42%
• Proteins 16%
• Gene encoding 16%
• Antibiotics 12%
• Gene expression 9%
• Personnel 6%

Chemical Compounds

• Donor 48%
• Dideoxynucleotide DNA Sequencing 30%
• Doxycycline 25%
• Mutation 14%
• Protein 14%
• Antimicrobial Agent 12%