Effects of 4-methylpyrazole, methanol/ethylene glycol antidote, in healthy humans

Dag Jacobsen, C. Simon Sebastian, Susan K. Barron, Edward W. Carriere, Kenneth E. McMartin

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

4-Methylpyrazole (4-MP), an inhibitor of alcohol dehydrogenase, may be useful for the treatment of methanol and ethylene glycol intoxications. A placebo-controlled, double blind, multiple dose, sequential, ascending-dose study has been performed to determine the tolerance of 4-MP in healthy volunteers. Oral loading doses of 4-MP were followed by supplemental doses every 12 h through 5 days, producing plasma levels in the therapeutic range. A slight, transient elevation in one or both serum transaminase values was observed in 6 of the 15 subjects treated with 4-MP. This effect was not dose related nor apparently mediated through a hypersensitivity reaction. Serum triglyceride levels were increased in 30% of 4-MP treated subjects, but also in 25% of the placebo subjects. 4-MP treatment did not produce any other significant changes in objective clinical parameters nor in subjective side effects. The results suggest that a mild, transient increase in liver function tests might be observed in some subjects treated with multiple doses of 4-MP. Nevertheless, the slower elimination rate and lesser degree of toxicity of 4-MP would make it preferable to ethanol in therapy of these poisonings.

Original languageEnglish (US)
Pages (from-to)455-461
Number of pages7
JournalJournal of Emergency Medicine
Volume8
Issue number4
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Keywords

  • 4-methylpyrazole
  • antidote
  • clinical toxicology study
  • ethylene glycol poisoning
  • methanol poisoning

ASJC Scopus subject areas

  • Emergency Medicine

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