Effects of 4-methylpyrazole, methanol/ethylene glycol antidote, in healthy humans

Dag Jacobsen, C Simon Sebastian, Susan K. Barron, Edward W. Carriere, Kenneth E. McMartin

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

4-Methylpyrazole (4-MP), an inhibitor of alcohol dehydrogenase, may be useful for the treatment of methanol and ethylene glycol intoxications. A placebo-controlled, double blind, multiple dose, sequential, ascending-dose study has been performed to determine the tolerance of 4-MP in healthy volunteers. Oral loading doses of 4-MP were followed by supplemental doses every 12 h through 5 days, producing plasma levels in the therapeutic range. A slight, transient elevation in one or both serum transaminase values was observed in 6 of the 15 subjects treated with 4-MP. This effect was not dose related nor apparently mediated through a hypersensitivity reaction. Serum triglyceride levels were increased in 30% of 4-MP treated subjects, but also in 25% of the placebo subjects. 4-MP treatment did not produce any other significant changes in objective clinical parameters nor in subjective side effects. The results suggest that a mild, transient increase in liver function tests might be observed in some subjects treated with multiple doses of 4-MP. Nevertheless, the slower elimination rate and lesser degree of toxicity of 4-MP would make it preferable to ethanol in therapy of these poisonings.

Original languageEnglish (US)
Pages (from-to)455-461
Number of pages7
JournalJournal of Emergency Medicine
Volume8
Issue number4
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Antidotes
Ethylene Glycol
Methanol
Placebos
fomepizole
Alcohol Dehydrogenase
Liver Function Tests
Therapeutics
Transaminases
Serum
Poisoning
Healthy Volunteers
Hypersensitivity
Triglycerides
Ethanol

Keywords

  • 4-methylpyrazole
  • antidote
  • clinical toxicology study
  • ethylene glycol poisoning
  • methanol poisoning

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Effects of 4-methylpyrazole, methanol/ethylene glycol antidote, in healthy humans. / Jacobsen, Dag; Sebastian, C Simon; Barron, Susan K.; Carriere, Edward W.; McMartin, Kenneth E.

In: Journal of Emergency Medicine, Vol. 8, No. 4, 01.01.1990, p. 455-461.

Research output: Contribution to journalArticle

Jacobsen, Dag ; Sebastian, C Simon ; Barron, Susan K. ; Carriere, Edward W. ; McMartin, Kenneth E. / Effects of 4-methylpyrazole, methanol/ethylene glycol antidote, in healthy humans. In: Journal of Emergency Medicine. 1990 ; Vol. 8, No. 4. pp. 455-461.
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