Effects of a eucaloric reduced-carbohydrate diet on body composition and fat distribution in women with PCOS

Amy M. Goss, Paula C. Chandler-Laney, Fernando Ovalle, Laura Lee Goree, Ricardo Azziz, Renee A. Desmond, G. Wright Bates, Barbara A. Gower

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Objective To determine if consumption of a reduced-carbohydrate (CHO) diet would result in preferential loss of adipose tissue under eucaloric conditions, and whether changes in adiposity were associated with changes in postprandial insulin concentration.

Methods In a crossover-diet intervention, 30 women with PCOS consumed a reduced-CHO diet (41:19:40% energy from CHO:protein:fat) for 8 weeks and a standard diet (55:18:27) for 8 weeks. Body composition by DXA and fat distribution by CT were assessed at baseline and following each diet phase. Insulin AUC was obtained from a solid meal test (SMT) during each diet phase.

Results Participants lost 3.7% and 2.2% total fat following the reduced-CHO diet and STD diet, resp. (p < 0.05 for difference between diets). The reduced-CHO diet induced a decrease in subcutaneous-abdominal, intra-abdominal, and thigh-intermuscular adipose tissue (- 7.1%, - 4.6%, and - 11.5%, resp.), and the STD diet induced a decrease in total lean mass. Loss of fat mass following the reduced CHO diet arm was associated with lower insulin AUC (p < 0.05) during the SMT.

Conclusions In women with PCOS, consumption of a diet lower in CHO resulted in preferential loss of fat mass from metabolically harmful adipose depots, whereas a diet high in CHO appeared to promote repartitioning of lean mass to fat mass.

Original languageEnglish (US)
Pages (from-to)1257-1264
Number of pages8
JournalMetabolism: Clinical and Experimental
Volume63
Issue number10
DOIs
StatePublished - Jan 1 2014

Keywords

  • Intra-abdominal adipose tissue
  • Macronutrient composition
  • Obesity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Goss, A. M., Chandler-Laney, P. C., Ovalle, F., Goree, L. L., Azziz, R., Desmond, R. A., Wright Bates, G., & Gower, B. A. (2014). Effects of a eucaloric reduced-carbohydrate diet on body composition and fat distribution in women with PCOS. Metabolism: Clinical and Experimental, 63(10), 1257-1264. https://doi.org/10.1016/j.metabol.2014.07.007