Effects of a new calcium antagonist, CD-832, on experimental coronary artery spasm in miniature pigs

Teisuke Takahashi, Thoru Fukai, Hiroshi Hata, Hiromitu Kasuya, Takeshi Kuga, Kensuke Egashira, Akira Takeshita

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The effects of a new calcium antagonist, CD-832, on experimental coronary artery spasms were studied in Göttingen miniature pigs. Pigs underwent endothelial denudation at the left anterior descending coronary artery using a balloon catheter. Changes in the diameter of the denuded and nondenuded site in response to an intracoronary administration of serotonin (10 μg/kg) or histamine (10 μg/kg) were assessed quantitatively by selective coronary arteriography 1 week after endothelial denudation. Percent reductions of the coronary artery diameter induced by serotonin or histamine in the denuded site were significantly greater than those in the nondenuded site (p<0.01). Coronary artery spasm induced by serotonin or histamine in the denuded site was attenuated in a dose-dependent manner by intravenous infusion of CD-832 (10 and 30 μg/kg/min) or nifedipine (1 and 3 μg/kg/min). The degrees of inhibition of coronary artery spasm by CD-832 were similar to those produced by nifedipine. CD-832 and nifedipine at the high dose caused comparable increases in the basal coronary artery diameter. These results suggest that CD-832 may be a useful drug for the treatment of coronary artery spasm.

Original languageEnglish (US)
Pages (from-to)265-271
Number of pages7
JournalCardiovascular Drugs and Therapy
Volume7
Issue number2
DOIs
StatePublished - Apr 1993
Externally publishedYes

Keywords

  • CD-832
  • calcium antagonist
  • coronary artery spasm
  • nifedipine

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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