Effects of adsorbed and templated nanosilver in mesoporous calcium-silicate nanoparticles on inhibition of bacteria colonization of dentin

Wei Fan, Daming Wu, Franklin Chi Meng Tay, Tengjiao Ma, Yujie Wu, Bing Fan

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Mesoporous calcium-silicate nanoparticles (MCSNs) are advanced biomaterials for controlled drug delivery and mineralization induction. Nanosilver-incorporated MCSNs (Ag-MCSNs) were prepared in the present study using both the adsorption and template methods. Both versions of Ag-MCSNs showed characteristic morphology of mesoporous materials and exhibited sustained release of ions over time. In antibacterial testing against planktonic Enterococcus faecalis, Ag-MCSNs showed significantly better antibacterial effects when compared with MCSNs (P<0.05). The Ag-MCSNs aggregated on the dentin surface of root canal walls and infiltrated into dentinal tubules after ultrasound activation, significantly inhibiting the adherence and colonization of E. faecalis on dentin (P<0.05). Despite this, Ag-MCSNs with templated nanosilver showed much lower cytotoxicity than Ag-MCSNs with adsorbed nanosilver (P<0.05). The results of the present study indicated that nanosilver could be incorporated into MCSNs using the template method. The templated nanosilver could release silver ions and inhibit the growth and colonization of E. faecalis both in the planktonic form and as biofilms on dentin surfaces as absorbed nanosilver. Templated Ag-MCSNs may be developed into a new intracanal disinfectant for root canal disinfection due to their antibacterial ability and low cytotoxicity, and as controlled release devices for other bioactive molecules to produce multifunctional biomaterials.

Original languageEnglish (US)
Pages (from-to)5217-5230
Number of pages14
JournalInternational journal of nanomedicine
Volume9
DOIs
StatePublished - Jan 1 2014

Fingerprint

Calcium silicate
Dentin
Nanoparticles
Bacteria
Enterococcus faecalis
Dental Pulp Cavity
Biocompatible Materials
Canals
Cytotoxicity
Biomaterials
calcium silicate
Ions
Controlled drug delivery
Disinfectants
Mesoporous materials
Disinfection
Biofilms
Silver
Adsorption
Ultrasonics

Keywords

  • antibacterial effect
  • mesoporosity
  • root canal
  • silver

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

Cite this

Effects of adsorbed and templated nanosilver in mesoporous calcium-silicate nanoparticles on inhibition of bacteria colonization of dentin. / Fan, Wei; Wu, Daming; Tay, Franklin Chi Meng; Ma, Tengjiao; Wu, Yujie; Fan, Bing.

In: International journal of nanomedicine, Vol. 9, 01.01.2014, p. 5217-5230.

Research output: Contribution to journalArticle

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