Effects of anomalous language representation on neuropsychological performance in temporal lobe epilepsy

David W. Loring, E. Strauss, B. P. Hermann, K. Perrine, M. R. Trenerry, W. B. Barr, M. Westerveld, G. J. Chelune, G. P. Lee, K. J. Meador

Research output: Contribution to journalArticle

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Abstract

Objective: To examine the effects of anomalous language representation (i.e., mixed- and right-cerebral dominant) on neuropsychological performance. Background: Right cerebral language dominance resulting from early cerebral injury is associated with relatively preserved language function with decreased visuospatial ability. However, previous reports of this phenomenon have examined patients with relatively large cerebral injuries (e.g., infantile hemiplegia) or limited sample sizes. Methods: A total of 561 patients with complex partial seizures of left temporal lobe origin were studied. Patients were classified into left (n = 455), bilateral (n = 58), and right (n = 48) language dominant groups based on Wada testing. Results: Right language dominant patients performed more poorly on multiple tests of visuospatial function, including Performance IQ (PIQ), than did left language patients. No significant group differences were detected for measures of language or general verbal function. The effects of bilateral language on PIQ differed according to handedness. Lowered PIQ was present in the bilateral nondextral group but not for bilateral dextral patients, and this pattern was observed with other visuospatial measures. Conclusions: In patients with relatively small lesions restricted to the left mesial temporal lobe, a shift in language dominance to the right hemisphere is associated with decreased visuospatial functions but preserved verbal abilities. Nondextral patients with bilateral language representation also displayed decreased visuospatial performance, although dextral patients with bilateral language did not.

Original languageEnglish (US)
Pages (from-to)260-264
Number of pages5
JournalNeurology
Volume53
Issue number2
StatePublished - Jul 22 1999

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Temporal Lobe Epilepsy
Language
Aptitude
Temporal Lobe
Cerebral Dominance
Functional Laterality
Hemiplegia
Wounds and Injuries
Sample Size
Seizures

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Loring, D. W., Strauss, E., Hermann, B. P., Perrine, K., Trenerry, M. R., Barr, W. B., ... Meador, K. J. (1999). Effects of anomalous language representation on neuropsychological performance in temporal lobe epilepsy. Neurology, 53(2), 260-264.

Effects of anomalous language representation on neuropsychological performance in temporal lobe epilepsy. / Loring, David W.; Strauss, E.; Hermann, B. P.; Perrine, K.; Trenerry, M. R.; Barr, W. B.; Westerveld, M.; Chelune, G. J.; Lee, G. P.; Meador, K. J.

In: Neurology, Vol. 53, No. 2, 22.07.1999, p. 260-264.

Research output: Contribution to journalArticle

Loring, DW, Strauss, E, Hermann, BP, Perrine, K, Trenerry, MR, Barr, WB, Westerveld, M, Chelune, GJ, Lee, GP & Meador, KJ 1999, 'Effects of anomalous language representation on neuropsychological performance in temporal lobe epilepsy', Neurology, vol. 53, no. 2, pp. 260-264.
Loring DW, Strauss E, Hermann BP, Perrine K, Trenerry MR, Barr WB et al. Effects of anomalous language representation on neuropsychological performance in temporal lobe epilepsy. Neurology. 1999 Jul 22;53(2):260-264.
Loring, David W. ; Strauss, E. ; Hermann, B. P. ; Perrine, K. ; Trenerry, M. R. ; Barr, W. B. ; Westerveld, M. ; Chelune, G. J. ; Lee, G. P. ; Meador, K. J. / Effects of anomalous language representation on neuropsychological performance in temporal lobe epilepsy. In: Neurology. 1999 ; Vol. 53, No. 2. pp. 260-264.
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