Effects of biogenic amines, FMRFamide and acetylcholine on the radula protractor muscle of a whelk

Gregg T. Nagle, Michael J. Greenberg

Research output: Contribution to journalArticle

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1. 1. The muscle was isolated from the southern whelk, Busycon contrarium. 2. 2. Dopamine (DA) elicits a single phasic contraction that is rapidly desentisized at high drug concentrations. Such desensitized preparations still respond to acetylcholine (ACh) and the molluscan neuropeptide FMRFamide. The evidence suggests the existence of an excitatory DA receptor. 3. 3. Muscles in FMRFamide or ACh contraction are relaxed by 5-hydroxytryptamine, phenylethylamines and catecholamines in a dose-dependent manner; a single phasic contraction precedes the catecholamine relaxation of such muscles. 4. 4. The responsesto FMRFamide, ACh and DA are sodium dependent; FMMFamide responses are more calcium dependent than ACh or DA.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalComparative Biochemistry and Physiology. Part C, Comparative
Issue number1
StatePublished - 1982
Externally publishedYes


ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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