Effects of biogenic amines, FMRFamide and acetylcholine on the radula protractor muscle of a whelk

Gregg Thomas Nagle, Michael J. Greenberg

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

1. 1. The muscle was isolated from the southern whelk, Busycon contrarium. 2. 2. Dopamine (DA) elicits a single phasic contraction that is rapidly desentisized at high drug concentrations. Such desensitized preparations still respond to acetylcholine (ACh) and the molluscan neuropeptide FMRFamide. The evidence suggests the existence of an excitatory DA receptor. 3. 3. Muscles in FMRFamide or ACh contraction are relaxed by 5-hydroxytryptamine, phenylethylamines and catecholamines in a dose-dependent manner; a single phasic contraction precedes the catecholamine relaxation of such muscles. 4. 4. The responsesto FMRFamide, ACh and DA are sodium dependent; FMMFamide responses are more calcium dependent than ACh or DA.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume73
Issue number1
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

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FMRFamide
Biogenic Amines
Acetylcholine
Muscles
Dopamine
Catecholamines
Phenethylamines
Muscle Relaxation
Dopamine Receptors
Neuropeptides
Serotonin
Sodium
Calcium
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Effects of biogenic amines, FMRFamide and acetylcholine on the radula protractor muscle of a whelk. / Nagle, Gregg Thomas; Greenberg, Michael J.

In: Comparative Biochemistry and Physiology. Part C, Comparative, Vol. 73, No. 1, 01.01.1982, p. 17-21.

Research output: Contribution to journalArticle

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