Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons

Julietta Uta Frey, Y. Y. Huang, E. R. Kandel

Research output: Contribution to journalArticle

939 Citations (Scopus)

Abstract

Hippocampal long-term potentiation (LTP) is thought to serve as an elementary mechanism for the establishment of certain forms of explicit memory in the mammalian brain. As is the case with behavioral memory, LTP in the CA1 region has stages: a short-term early potentiation lasting 1 to 3 hours, which is independent of protein synthesis, precedes a later, longer lasting stage (L-LTP), which requires protein synthesis. Inhibitors of cyclic adenosine monophosphate (cAMP) - dependent protein kinase (PKA) blocked L-LTP, and analogs of cAMP induced a potentiation that blocked naturally induced L-LTP. The action of the cAMP analog was blocked by inhibitors of protein synthesis. Thus, activation of PKA may be a component of the mechanism that generates L-LTP.

Original languageEnglish (US)
Pages (from-to)1661-1664
Number of pages4
JournalScience
Volume260
Issue number5114
DOIs
StatePublished - Jan 1 1993

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Long-Term Potentiation
Cyclic AMP
Neurons
Protein Synthesis Inhibitors
Cyclic AMP-Dependent Protein Kinases
Protein Kinases
Proteins
Brain

ASJC Scopus subject areas

  • General

Cite this

Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. / Frey, Julietta Uta; Huang, Y. Y.; Kandel, E. R.

In: Science, Vol. 260, No. 5114, 01.01.1993, p. 1661-1664.

Research output: Contribution to journalArticle

Frey, JU, Huang, YY & Kandel, ER 1993, 'Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons', Science, vol. 260, no. 5114, pp. 1661-1664. https://doi.org/10.1126/science.8389057
Frey, Julietta Uta ; Huang, Y. Y. ; Kandel, E. R. / Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. In: Science. 1993 ; Vol. 260, No. 5114. pp. 1661-1664.
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