Effects of combined exposure to lead and cadmium on the hypothalamic-pituitary axis function in proestrous rats

Anilkumar R Pillai, L. Priya, Sarita Gupta

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Abstract

The effects of lead and cadmium on the hypothalamic-pituitary axis were studied in proestrous rats. Adult female rats were treated intraperitonially with either lead acetate and cadmium acetate alone or in combination at a dose of 0.05 mg/kg daily for 15 days. Serotonin (5-HT) and norepinephrine (NE) levels decreased in individually and combined metal treated groups whereas dopamine (DA) levels were decreased only in the cadmium-exposed group. The pituitary levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH) were decreased significantly in cadmium and combined treatment groups. In contrast, lead exposure failed to cause any change in serum LH and FSH levels, whereas cadmium and combined treatments showed significant decrease in serum LH and FSH levels as compared with control. The accumulation of both metals increased in the hypothalamus and pituitary after treatment. These data suggest that the metal accumulation disrupts the regulatory mechanisms of the hypothalamic-pituitary axis where the effects produced by the combined treatment of metals are not additive.

Original languageEnglish (US)
Pages (from-to)379-384
Number of pages6
JournalFood and Chemical Toxicology
Volume41
Issue number3
DOIs
StatePublished - Mar 1 2003

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Cadmium
Rats
cadmium
Follicle Stimulating Hormone
Luteinizing Hormone
Metals
follicle-stimulating hormone
luteinizing hormone
metals
rats
Serotonin
serotonin
lead acetate
Serum
Hypothalamus
Dopamine
Norepinephrine
hypothalamus
norepinephrine
dopamine

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Effects of combined exposure to lead and cadmium on the hypothalamic-pituitary axis function in proestrous rats. / Pillai, Anilkumar R; Priya, L.; Gupta, Sarita.

In: Food and Chemical Toxicology, Vol. 41, No. 3, 01.03.2003, p. 379-384.

Research output: Contribution to journalArticle

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