Effects of diabetic ketoacidosis on visual and verbal neurocognitive function in young patients presenting with new-onset type 1 diabetes

Ashley B. Jessup, Mary Beth Grimley, Echo Meyer, Gregory G Passmore, Ayşenil Belger, William H. Hoffman, Ali S. Çalıkoğlu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: To evaluate the effects of diabetic ketoacidosis (DKA) on neurocognitive functions in children and adolescents presenting with newonset type 1 diabetes. Methods: Newly diagnosed patients were divided into two groups: those with DKA and those without DKA (non-DKA). Following metabolic stabilization, the patients took a mini-mental status exam prior to undergoing a baseline battery of cognitive tests that evaluated visual and verbal cognitive tasks. Follow-up testing was performed 8-12 weeks after diagnosis. Patients completed an IQ test at follow-up. Results: There was no statistical difference between the DKA and non-DKA groups neither in alertness at baseline testing nor in an IQ test at followup. The DKA group had significantly lower baseline scores than the non-DKA group for the visual cognitive tasks of design recognition, design memory and the composite visual memory index (VMI). At follow-up, Design Recognition remained statistically lower in the DKA group, but the design memory and the VMI tasks returned to statistical parity between the two groups. No significant differences were found in verbal cognitive tasks at baseline or follow-up between the two groups. Direct correlations were present for the admission CO2 and the visual cognitive tasks of VMI, design memory and design recognition. Direct correlations were also present for admission pH and VMI, design memory and picture memory. Conclusion: Pediatric patients presenting with newly diagnosed type 1 diabetes and severe but uncomplicated DKA showed a definite trend for lower cognitive functioning when compared to the age-matched patients without DKA.

Original languageEnglish (US)
Pages (from-to)203-210
Number of pages8
JournalJCRPE Journal of Clinical Research in Pediatric Endocrinology
Volume7
Issue number3
DOIs
StatePublished - Sep 1 2015

Fingerprint

Diabetic Ketoacidosis
Type 1 Diabetes Mellitus
Ketosis
Parity
Pediatrics

Keywords

  • Cognition
  • Dehydration
  • Diabetic ketoacidosis
  • Neuroinflammation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Effects of diabetic ketoacidosis on visual and verbal neurocognitive function in young patients presenting with new-onset type 1 diabetes. / Jessup, Ashley B.; Grimley, Mary Beth; Meyer, Echo; Passmore, Gregory G; Belger, Ayşenil; Hoffman, William H.; Çalıkoğlu, Ali S.

In: JCRPE Journal of Clinical Research in Pediatric Endocrinology, Vol. 7, No. 3, 01.09.2015, p. 203-210.

Research output: Contribution to journalArticle

Jessup, Ashley B. ; Grimley, Mary Beth ; Meyer, Echo ; Passmore, Gregory G ; Belger, Ayşenil ; Hoffman, William H. ; Çalıkoğlu, Ali S. / Effects of diabetic ketoacidosis on visual and verbal neurocognitive function in young patients presenting with new-onset type 1 diabetes. In: JCRPE Journal of Clinical Research in Pediatric Endocrinology. 2015 ; Vol. 7, No. 3. pp. 203-210.
@article{2332585c395f4701b620a4b914b8f09b,
title = "Effects of diabetic ketoacidosis on visual and verbal neurocognitive function in young patients presenting with new-onset type 1 diabetes",
abstract = "Objective: To evaluate the effects of diabetic ketoacidosis (DKA) on neurocognitive functions in children and adolescents presenting with newonset type 1 diabetes. Methods: Newly diagnosed patients were divided into two groups: those with DKA and those without DKA (non-DKA). Following metabolic stabilization, the patients took a mini-mental status exam prior to undergoing a baseline battery of cognitive tests that evaluated visual and verbal cognitive tasks. Follow-up testing was performed 8-12 weeks after diagnosis. Patients completed an IQ test at follow-up. Results: There was no statistical difference between the DKA and non-DKA groups neither in alertness at baseline testing nor in an IQ test at followup. The DKA group had significantly lower baseline scores than the non-DKA group for the visual cognitive tasks of design recognition, design memory and the composite visual memory index (VMI). At follow-up, Design Recognition remained statistically lower in the DKA group, but the design memory and the VMI tasks returned to statistical parity between the two groups. No significant differences were found in verbal cognitive tasks at baseline or follow-up between the two groups. Direct correlations were present for the admission CO2 and the visual cognitive tasks of VMI, design memory and design recognition. Direct correlations were also present for admission pH and VMI, design memory and picture memory. Conclusion: Pediatric patients presenting with newly diagnosed type 1 diabetes and severe but uncomplicated DKA showed a definite trend for lower cognitive functioning when compared to the age-matched patients without DKA.",
keywords = "Cognition, Dehydration, Diabetic ketoacidosis, Neuroinflammation",
author = "Jessup, {Ashley B.} and Grimley, {Mary Beth} and Echo Meyer and Passmore, {Gregory G} and Ayşenil Belger and Hoffman, {William H.} and {\cC}alıkoğlu, {Ali S.}",
year = "2015",
month = "9",
day = "1",
doi = "10.4274/jcrpe.2158",
language = "English (US)",
volume = "7",
pages = "203--210",
journal = "JCRPE Journal of Clinical Research in Pediatric Endocrinology",
issn = "1308-5727",
publisher = "Galenos Yayincilik",
number = "3",

}

TY - JOUR

T1 - Effects of diabetic ketoacidosis on visual and verbal neurocognitive function in young patients presenting with new-onset type 1 diabetes

AU - Jessup, Ashley B.

AU - Grimley, Mary Beth

AU - Meyer, Echo

AU - Passmore, Gregory G

AU - Belger, Ayşenil

AU - Hoffman, William H.

AU - Çalıkoğlu, Ali S.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Objective: To evaluate the effects of diabetic ketoacidosis (DKA) on neurocognitive functions in children and adolescents presenting with newonset type 1 diabetes. Methods: Newly diagnosed patients were divided into two groups: those with DKA and those without DKA (non-DKA). Following metabolic stabilization, the patients took a mini-mental status exam prior to undergoing a baseline battery of cognitive tests that evaluated visual and verbal cognitive tasks. Follow-up testing was performed 8-12 weeks after diagnosis. Patients completed an IQ test at follow-up. Results: There was no statistical difference between the DKA and non-DKA groups neither in alertness at baseline testing nor in an IQ test at followup. The DKA group had significantly lower baseline scores than the non-DKA group for the visual cognitive tasks of design recognition, design memory and the composite visual memory index (VMI). At follow-up, Design Recognition remained statistically lower in the DKA group, but the design memory and the VMI tasks returned to statistical parity between the two groups. No significant differences were found in verbal cognitive tasks at baseline or follow-up between the two groups. Direct correlations were present for the admission CO2 and the visual cognitive tasks of VMI, design memory and design recognition. Direct correlations were also present for admission pH and VMI, design memory and picture memory. Conclusion: Pediatric patients presenting with newly diagnosed type 1 diabetes and severe but uncomplicated DKA showed a definite trend for lower cognitive functioning when compared to the age-matched patients without DKA.

AB - Objective: To evaluate the effects of diabetic ketoacidosis (DKA) on neurocognitive functions in children and adolescents presenting with newonset type 1 diabetes. Methods: Newly diagnosed patients were divided into two groups: those with DKA and those without DKA (non-DKA). Following metabolic stabilization, the patients took a mini-mental status exam prior to undergoing a baseline battery of cognitive tests that evaluated visual and verbal cognitive tasks. Follow-up testing was performed 8-12 weeks after diagnosis. Patients completed an IQ test at follow-up. Results: There was no statistical difference between the DKA and non-DKA groups neither in alertness at baseline testing nor in an IQ test at followup. The DKA group had significantly lower baseline scores than the non-DKA group for the visual cognitive tasks of design recognition, design memory and the composite visual memory index (VMI). At follow-up, Design Recognition remained statistically lower in the DKA group, but the design memory and the VMI tasks returned to statistical parity between the two groups. No significant differences were found in verbal cognitive tasks at baseline or follow-up between the two groups. Direct correlations were present for the admission CO2 and the visual cognitive tasks of VMI, design memory and design recognition. Direct correlations were also present for admission pH and VMI, design memory and picture memory. Conclusion: Pediatric patients presenting with newly diagnosed type 1 diabetes and severe but uncomplicated DKA showed a definite trend for lower cognitive functioning when compared to the age-matched patients without DKA.

KW - Cognition

KW - Dehydration

KW - Diabetic ketoacidosis

KW - Neuroinflammation

UR - http://www.scopus.com/inward/record.url?scp=84940386184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940386184&partnerID=8YFLogxK

U2 - 10.4274/jcrpe.2158

DO - 10.4274/jcrpe.2158

M3 - Article

VL - 7

SP - 203

EP - 210

JO - JCRPE Journal of Clinical Research in Pediatric Endocrinology

JF - JCRPE Journal of Clinical Research in Pediatric Endocrinology

SN - 1308-5727

IS - 3

ER -