TY - JOUR
T1 - Effects of different growth factors and carriers on bone regeneration
T2 - A systematic review
AU - Khojasteh, Arash
AU - Behnia, Hossein
AU - Naghdi, Navid
AU - Esmaeelinejad, Mohammad
AU - Alikhassy, Zahra
AU - Stevens, Mark
PY - 2013/12
Y1 - 2013/12
N2 - Objective: The application and subsequent investigations in the use of varied osteogenic growth factors in bone regeneration procedures have grown dramatically over the past several years. Owing to this rapid gain in popularity and documentation, a review was undertaken to evaluate the in vivo effects of growth factors on bone regeneration. Study Design: Using related key words, electronic databases (Medline, Embase, and Cochrane) were searched for articles published from 1999 to April 2010 to find growth factor application in bone regeneration in human or animal models. Results: A total of 63 articles were matched with the inclusion criteria of this study. Bone morphogenetic protein 2 (BMP-2) was the most studied growth factor. Carriers for the delivery, experimental sites, and methods of evaluation were different, and therefore articles did not come to a general agreement. Conclusions: Within the limitations of this review, BMP-2 may be an appropriate growth factor for osteogenesis.
AB - Objective: The application and subsequent investigations in the use of varied osteogenic growth factors in bone regeneration procedures have grown dramatically over the past several years. Owing to this rapid gain in popularity and documentation, a review was undertaken to evaluate the in vivo effects of growth factors on bone regeneration. Study Design: Using related key words, electronic databases (Medline, Embase, and Cochrane) were searched for articles published from 1999 to April 2010 to find growth factor application in bone regeneration in human or animal models. Results: A total of 63 articles were matched with the inclusion criteria of this study. Bone morphogenetic protein 2 (BMP-2) was the most studied growth factor. Carriers for the delivery, experimental sites, and methods of evaluation were different, and therefore articles did not come to a general agreement. Conclusions: Within the limitations of this review, BMP-2 may be an appropriate growth factor for osteogenesis.
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U2 - 10.1016/j.oooo.2012.01.044
DO - 10.1016/j.oooo.2012.01.044
M3 - Review article
C2 - 22901644
AN - SCOPUS:84887995398
SN - 2212-4403
VL - 116
SP - e405-e423
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
IS - 6
ER -