Effects of environmental enrichment on gene expression in the brain

Claire Rampon, Cecilia H. Jiang, Helin Dong, Ya Ping Tang, David J. Lockhart, Peter G. Schultz, Joseph Zhuo Tsien, Yinghe Hu

Research output: Contribution to journalArticlepeer-review

496 Scopus citations


An enriched environment is known to promote structural changes in the brain and to enhance learning and memory performance in rodents [Hebb, D. O. (1947) Am. Psychol. 2, 305-307]. To better understand the molecular mechanisms underlying these experience-dependent cognitive changes, we have used high-density oligonucleotide microarrays to analyze gene expression in the brain. Expression of a large number of genes changes in response to enrichment training, many of which can be linked to neuronal structure, synaptic plasticity, and transmission. A number of these genes may play important roles in modulating learning and memory capacity.

Original languageEnglish (US)
Pages (from-to)12880-12884
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number23
StatePublished - Nov 7 2000
Externally publishedYes

ASJC Scopus subject areas

  • General


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