Effects of environmental enrichment on gene expression in the brain

Claire Rampon, Cecilia H. Jiang, Helin Dong, Ya Ping Tang, David J. Lockhart, Peter G. Schultz, Joseph Zhuo Tsien, Yinghe Hu

Research output: Contribution to journalArticle

433 Citations (Scopus)

Abstract

An enriched environment is known to promote structural changes in the brain and to enhance learning and memory performance in rodents [Hebb, D. O. (1947) Am. Psychol. 2, 305-307]. To better understand the molecular mechanisms underlying these experience-dependent cognitive changes, we have used high-density oligonucleotide microarrays to analyze gene expression in the brain. Expression of a large number of genes changes in response to enrichment training, many of which can be linked to neuronal structure, synaptic plasticity, and transmission. A number of these genes may play important roles in modulating learning and memory capacity.

Original languageEnglish (US)
Pages (from-to)12880-12884
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number23
DOIs
StatePublished - Nov 7 2000
Externally publishedYes

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Learning
Gene Expression
Neuronal Plasticity
Brain
Microarray Analysis
Oligonucleotide Array Sequence Analysis
Synaptic Transmission
Genes
Rodentia

ASJC Scopus subject areas

  • General

Cite this

Rampon, C., Jiang, C. H., Dong, H., Tang, Y. P., Lockhart, D. J., Schultz, P. G., ... Hu, Y. (2000). Effects of environmental enrichment on gene expression in the brain. Proceedings of the National Academy of Sciences of the United States of America, 97(23), 12880-12884. https://doi.org/10.1073/pnas.97.23.12880

Effects of environmental enrichment on gene expression in the brain. / Rampon, Claire; Jiang, Cecilia H.; Dong, Helin; Tang, Ya Ping; Lockhart, David J.; Schultz, Peter G.; Tsien, Joseph Zhuo; Hu, Yinghe.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 23, 07.11.2000, p. 12880-12884.

Research output: Contribution to journalArticle

Rampon, Claire ; Jiang, Cecilia H. ; Dong, Helin ; Tang, Ya Ping ; Lockhart, David J. ; Schultz, Peter G. ; Tsien, Joseph Zhuo ; Hu, Yinghe. / Effects of environmental enrichment on gene expression in the brain. In: Proceedings of the National Academy of Sciences of the United States of America. 2000 ; Vol. 97, No. 23. pp. 12880-12884.
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