Abstract
The effects of estradiol, 2-hydroxyestrone (2-OH-E1) and tail-pinch (TP) on dopamine (DA) neuron firing rates in the substantia nigra compacta (SNC) were examined. 17-beta-estradiol, 2-OH-El, and TP stimuli produced rapid changes in DA-cell firing rates whereas 17-alpha-estradiol and clomiphene had little effect. Our data demonstrate that 2-OH-El can produce similar changes in the SNC DA-cell activity as estrogen and that TP stimuli produce reliable changes in DA-cell firing rates that are dissociated from those induced by intravenous estrogen.
Original language | English (US) |
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Pages (from-to) | 313-316 |
Number of pages | 4 |
Journal | Research Communications in Psychology, Psychiatry and Behavior |
Volume | 13 |
Issue number | 4 |
State | Published - Jan 1 1988 |
Externally published | Yes |
ASJC Scopus subject areas
- Psychiatry and Mental health